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008			180628s2018 si | s |||| 0|eng d
020			_a9789811305931 _9
024	7		_a10.1007/978-981-13-0593-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aRB155 2018 EB
245	1	0	_aChromosome Translocation _cedited by Yu Zhang.
264		1	_aSingapore _bSpringer International Publishing _c2018
300			_a1 recurso en línea (V, 168 páginas 29 ilustraciones,27 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1044
505	0		_aChapter 1: Historical and clinical overview of chromosome translocations -- Chapter 2: Next generation sequencing to identify chromosome translocation -- Chapter 3: The experimental models to study chromosome translocations -- Chapter 4: High throughput translocation sequencing to identify mechanistic factors shaping translocatome -- Chapter 5: Live cell imaging to study chromosome translocation -- Chapter 6: CRISPR/Cas9 to induce chromosome translocation in vivo -- Chapter 7: Generation of DNA double strand breaks (DSBs) -- Chapter 8: The role of DSB response pathway in regulating chromosome translocation -- Chapter 9: DSB repair and ligation of chromosome translocation -- Chapter 10: 3D genome organization defines the chromosome translocation pattern -- Chapter 11: Mechanisms of chromosome deletion -- Chapter 12: Chromothripsis: The role of DNA double strand break form on repair pathway selection.
520	3		_aThis volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases. The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation. It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.
650		7	_aGenética humana _2embne _9140562
650		7	_aCitología _2embne _9139477
700	1		_aZhang, Yu _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/no00026520 _1http://viaf.org/viaf/67788294
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9789811305924
776	0	8	_iEdición impresa: _z9789811305948
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-0593-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
988			_aEBSPRINGER_2018
998			_aSI _b02/2019 _cm _dz _ep _feng _ggw _h0
999			_c100935 _d100935 _x1