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007			cr nn nnnaamaa
008			180628s2018 si | s |||| 0|eng d
020			_a9789811055263 _9
024	7		_a10.1007/978-981-10-5526-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQP34 2018 EB
245	1	0	_aDevelopmental Origins of Health and Disease (DOHaD) : _bFrom Biological Basis to Clinical Significance _cedited by Takeo Kubota, Hideoki Fukuoka.
264		1	_aSingapore _bSpringer International Publishing _c2018
300			_a1 recurso en línea (VII, 95 páginas 23 ilustraciones,16 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1012
505	0		_aPart 1 Biological Basis -- One carbon metabolism and lipid metabolism in DOHaD -- Novel models of epigenetic gene regulation in the nutritional environment -- Epigenetic switching and neonatal nutritional environment -- Part 2 Disease and environment -- Developmental Origins of Non-Alcoholic Fatty Liver Disease (NAFLD) -- Fetal origins of hypertension -- Involvement of noncoding RNAs in stress-related neuropsychiatric diseases caused by DOCaD theory -- Part 3 Transgenerational mechanism and its consequences -- Placental development and nutritional environment -- Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm -- Part 4 Clinical Significance -- Preemptive epigenetic medicine based on fetal programming.
520	3		_aThis book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.
650		7	_aFisiología humana _2embne _9140024
650		7	_9162368 _aBiología del desarrollo _2embne
700	1		_aKubota, Takeo _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2018187571 _1http://viaf.org/viaf/5153773415461430466
700	1		_aFukuoka, Hideoki _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _1http://viaf.org/viaf/290819742
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9789811055256
776	0	8	_iEdición impresa: _z9789811055270
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-10-5526-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
988			_aEBSPRINGER_2018
998			_aSI _b02/2019 _cm _dz _ep _feng _ggw _h0
999			_c100932 _d100932 _x1