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001			100924
003			ESmaUEC
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007			cr nn nnnaamaa
008			180627s2018 gw | s |||| 0|eng d
020			_a9783319906959 _9
024	7		_a10.1007/978-3-319-90695-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQH588.S83 2018 EB
245	1	0	_aStem Cell Genetics for Biomedical Research : _bPast, Present, and Future _cedited by Raul Delgado-Morales.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XI, 426 páginas 32 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
505	0		_aPart I: Stem cells for brain disorders -- Chapter1: Human induced pluripotent stem cell-derived neurons to model and gain insights into Alzheimer's disease pathogenesis -- Chapter2: Modeling schizophrenia with human stem cells -- Chapter3: Rett Syndrome and Stem Cell research -- Chapter4: Stem Cell Applications in Spinal Cord Injury: A Primer -- Chapter5: Cell-Based Therapy for Retinal Degenerative Disease -- Chapter6: Past, present and future of cell based-therapy in progressive multiple sclerosis -- Part II: Stem cells for cardiovascular diseases -- Chapter7: Cardiac Stem Cells: a plethora of potential therapies for myocardial regeneration within reach -- Chapter8: Human Induced Pluripotent Stem Cell-derived Cardiomyocytes in the Evaluation of Cardiotoxic Potential of Drugs -- Part III: Stem cells for general medicine -- Chapter9: Regenerative medicine for diabetes treatment: new β-cell sources -- Chapter10: Dental pulp stem cells promote wound healing and muscle regeneration -- Chapter11: From bench to bedside of mesenchymal Stem Cells use for Rheumatoid Arthritis treatment -- Chapter12: Stem Cells and Cancer -- Chapter13: The relevance of induced pluripotent stem cells for the study of physiological and premature aging -- Part IV: Technical challenges and future -- Chapter14: Pluripotent stem cell banks -- Chapter15: Genetic and Epigenetic engineering: the CRISPR/Cas9 era.
520	3		_aThis book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer's disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.
650		7	_aCélulas madre _2embne _9160528
650		7	_aGenética humana _2embne _9140562
650		7	_aMedicina _2embne _9405021
700	1		_aDelgado-Morales, Raul _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/nb2017012897 _1http://viaf.org/viaf/32149912308506210094
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319906942
776	0	8	_iEdición impresa: _z9783319906966
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-90695-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
988			_aEBSPRINGER_2018
998			_aSI _b02/2019 _cm _dz _ep _feng _ggw _h0
999			_c100924 _d100924 _x1