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007			cr nn nnnaamaa
008			180626s2018 gw | s |||| 0|eng d
020			_a9783319777368
024	7		_a10.1007/978-3-319-77736-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC261 _b2018 EB
245	1	4	_aThe Heterogeneity of Cancer Metabolism _cedited by Anne Le.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XV, 183 páginas 31 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology, _x0065-2598 _v1063
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPart 1: The metabolism of cancer cells -- Chapter 1: Glucose Metabolism -- Chapter 2: Glutamine Metabolism -- Chapter 3: Amino Acid Metabolism -- Chapter 4: Lipid Metabolism -- Chapter 5: Epigenetics and oncometabolites -- Part 2: Heterogeneity of Cancer Metabolism - Chapter 1: Specific oncogenetic mutations lead to specific metabolic phenotypes within the same tissue of origin -- Chapter 2: Intratumoral heterogeneity of cancer cell metabolism -- - Chapter 3: Differential metabolism in vitro and in vivo -- Part 3: Carcinoma associated fibroblasts -- Chapter 1: Characteristics of CAF's -- Chapter 2: Reverse Warbug EFF -- Chapter 3: Metabolic exchange between CAFs and cancer cells. .
520	3		_aGenetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
988			_aEBSPRINGER_2018
650		7	_2embne _aOncología _9139207
700	1		_aLe, Anne. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2018188636
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _9106996
776	0	8	_iEdición impresa: _z9783319777351
776	0	8	_iEdición impresa: _z9783319777375
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-77736-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE