000			05065nam a22003855i 4500
001			100906
003			ESmaUEC
005			20230102113016.0
006			a||||fo|||| 00| 0
007			cr nn nnnaamaa
008			180321s2018 gw | s |||| 0|eng d
020			_a9783319733449 _9
024	7		_a10.1007/978-3-319-73344-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aRB147.5 2018 EB
245	1	0	_aMitochondrial Biology and Experimental Therapeutics _cedited by Paulo J. Oliveira.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (IX, 708 páginas 127 ilustraciones,106 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
505	0		_aTarget Mitochondria -- SECTION I-Mitochondrial Biology -- Introduction: Mitochondria: the cell furnace -- MItochondria: Where are They Coming From? -- Mitochondrial Dynamics: A journey from Mitochondrial Morphology to MItochondrial Function and Quality -- Mitochondrial ROS, Oxidative Stress.and Aging- The Mitochondrial Permeability Transition Pore -- Mitochondrial Regulation of Cell Death -- MItochondria in Liver Diseases -- Mitochondria in Liver Regeneration,Energy Metabolism, and Posthepatectomy Liver Dysfunction -- MItochondrial Remodeling in Cancer -- Mitochondria in Kidney Disease -- CNS diseases and disruption of Mitochondria -- Mitochondrial disruption in cardiovascular diseases -- .Drug-inducing Mitochondrial Toxicity -- MItochondrial DNA: Functions and Role in Acquired Diseases -- SECTION II-MItochondrial Therapeutics: From the Bench to Industry and Patient -- The Evolution of Mitochondrial Toxicity Assessment in Industry -- Designing Mitochondrial-Active Molecules: The Road to MitoQ and Beyond -- Recovering Mitochondrial Function in Patients' Fibroblasts -- Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity -- Modulation of Cell Fate by Tauroursodexycholic Acid: All Paths Lead to Mitochondria -- Pharmacological Targeting of the Mitchondrial Permeability Transition Pore -- Strategies to Preserve/Improve Mitochondrial Function in Organ Preservation Solutions -- MItochondrial Targeted Redox Active Compounds and the Astrocytemotoneuron Axis: relevance for the Treatment of Amyotrophic Lateral Sclerosis -- Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of the Mitochondrial Gene Experssion -- Mitochoncrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and other Natural Supplements -- Development of Mitochondrial-Directed Plastoquinones -- Targeted Mitochondrial Genome Editing -- Targeting Therpeutic Nucleic Acids into Mitochondria: A Long Challenge -- Cell Permeable Peptides Targeting Mitochondria -- MItochondrial -Directed Cancer Therapy -- SkQ1: The Road from the Bench to the Market -- MItochondrial Follies: Comic.
520	3		_aThis book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.
650		7	_aToxicología _2embne _9140328
650		7	_aBioquímica _2embne _9138639
650		7	_aCitología _2embne _9139477
700	1		_aOliveira, Paulo J _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/no2006129831 _1http://viaf.org/viaf/34222956
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319733432
776	0	8	_iEdición impresa: _z9783319733456
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-73344-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
988			_aEBSPRINGER_2018
998			_aSI _b02/2019 _cm _dz _ep _feng _ggw _h0
999			_c100906 _d100906 _x1