000			02957nam a22003615i 4500
001			100874
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007			cr nn nnnaamaa
008			180531s2018 si | s |||| 0|eng d
020			_a9789811300028 _9
024	7		_a10.1007/978-981-13-0002-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQP702.G56 2018 EB
245	1	0	_aGlucose-sensing Receptor in Pancreatic Beta-cells _cedited by Itaru Kojima.
264		1	_aSingapore _bSpringer International Publishing _c2018
300			_a1 recurso en línea (V, 71 páginas 15 ilustraciones,7 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
505	0		_a1 HISTORY OF THE RESEARCH ON THE GLUCOSE RECEPTOR -- 2 Cell-surface Glucoreceptor Recognizing Anomers of Glucose in Pancreatic b-cells -- 3 KATP CHANNEL-INDEPENDENT PATHWAY and THE GLUCORECEPTOR -- 4 Signaling System Activated by the Glucose-sensing Receptor -- 5 The Role of the Glucose-sensing Receptor in Glucose-induced Insulin Secretion in Pancreatic b-cells.
520	3		_aSince the 1970s, there has been much discussion about the "glucoreceptor" and "substrate site" and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the "glucoreceptor theory." This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: "glucoreceptor theory". Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes.
650		7	_aGluconeogenesis _9668478 _2embne
650		7	_aEndocrinología _2embne _9139372
700	1		_aKojima, Itaru. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/nr93008663 _1http://viaf.org/viaf/66338839
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9789811300011
776	0	8	_iEdición impresa: _z9789811300035
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-0002-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b04/2019 _cm _dz _ek _feng _ggw _h0
999			_c100874 _d100874 _x1