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003			ESmaUEC
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007			cr nn nnnaamaa
008			180425s2018 gw | s |||| 0|eng d
020			_a9783319732381 _9
024	7		_a10.1007/978-3-319-73238-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQR182.2.I46 2018 EB
245	1	0	_aAccelerated Path to Cures _cedited by Josep Bassaganya-Riera.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (VIII, 82 páginas 11 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
505	0		_aChapter 1: Introduction to Accelerated Path to Cures and Precision Medicine in Inflammatory Bowel Disease -- Chapter 2: Computer-Aided Drug Discovery -- Chapter 3: Preclinical Studies: Efficacy and Safety -- Chapter 4: From Nutritional Immunology to Drug Development -- Chapter 5: Development of Synthetic Patient Populations and In Silico Clinical Trials.
520	3		_aAccelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.
650		7	_aInmunología _2embne _9138330
650		7	_aBioinformática _2embne _9160489
650		7	_aHistorias clínicas _2embne _9142034
700	1		_aBassaganya-Riera, Josep. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2016183155 _1http://viaf.org/viaf/31146331921718692188
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319732374
776	0	8	_iEdición impresa: _z9783319732398
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-73238-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b04/2019 _cm _dz _ek _feng _ggw _h0
999			_c100824 _d100824 _x1