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008			180418s2018 gw | s |||| 0|eng d
020			_a9783319741642
024	7		_a10.1007/978-3-319-74164-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aRM1 _b2018 EB
245	1	0	_aTargeting Trafficking in Drug Development _cedited by Alfredo Ulloa-Aguirre, Ya-Xiong Tao.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (VIII, 425 páginas) _b57 ilustraciones
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF
490	0		_aHandbook of Experimental Pharmacology, _x0171-2004 _v245
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_a1. Intracellular trafficking of gonadotropin receptors in health and disease -- 2. Investigating internalization and intracellular trafficking of GPCRs -- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors -- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases -- 5. Pharmacoperones for misfolded gonadotropin receptors -- 6. Pharmacological chaperones: Beyond conformational disorders -- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer -- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches -- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking -- 10. SLC6 transporter folding diseases and pharmacochaperoning -- 11. The molecular physiopathogenesis of islet amyloidosis -- 12. Folding defects leading to primary hyperoxaluria -- 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. .
520	3		_aCellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.
650		7	_2embne _9331970 _aMedicamentos _xEnsayos clínicos
700	1		_aUlloa-Aguirre, Alfredo. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2014187062 _9666501
700	1		_aTao, Ya-Xiong. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/nb2010002168
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _9106996
776	0	8	_iEdición impresa: _z9783319741635
776	0	8	_iEdición impresa: _z9783319741659
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-74164-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc
988			_aEBSPRINGER_2018