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001			100814
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007			cr nn nnnaamaa
008			180514s2018 si | s |||| 0|eng d
020			_a9789811087523 _9
024	7		_a10.1007/978-981-10-8752-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aR856.A6 2018 EB
100	1		_aMarchisio, Mario Andrea _eautor _9668878
245	1	0	_aIntroduction to Synthetic Biology : _bAbout Modeling, Computation, and Circuit Design _cby Mario Andrea Marchisio.
264		1	_aSingapore _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XII, 187 páginas 91 ilustraciones,74 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aLearning Materials in Biosciences _x2509-6125
505	0		_aChapter 1: Introduction -- Chapter 2: Modeling: choosing a kinetics -- Chapter 3: Modeling at computer: getting started -- Chapter 4: Stochastic modeling -- Chapter 5: Steady states -- Chapter 6: Stability analysis: hysteresis and oscillations -- Chapter7: Toggle switch: dynamics and steady states -- Chapter 8: Rule-based modeling -- Chapter 9: Gene circuit modular computational design -- Chapter 10: Parameter analysis -- Chapter 11: Circuit analysis with COPASI -- Chapter 12: Circuit motifs.
520	3		_aThe textbook is based on the lectures of the course "Synthetic Biology" for Master's students in biology and biotechnology at the Harbin Institute of Technology. The goal of the textbook is to explain how to make mathematical models of synthetic gene circuits that will, later on, drive the circuit implementation in the lab. Concepts such as kinetics, circuit dynamics and equilibria, stochastic and deterministic simulations, parameter analysis and optimization are presented. At the end of the textbook, a chapter contains a description of structural motifs (e.g. positive and negative feedback loops, Boolean gates) that carry out specific functions and can be combined into larger networks. Moreover, several chapters show how to build up (an analyse, where possible) models for synthetic gene circuits with four different open-source software i.e. COPASI, XPPAUT, BioNetGeN, and Parts & Pools-ProMoT.
650		7	_aIngeniería biomédica _9143820 _embne _2embne
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9789811087516
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://dx.doi.org/10.1007/978-981-10-8752-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b04/2019 _cm _dz _ek _feng _ggw _h0
999			_c100814 _d100814 _x1