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008			180409s2018 gw | s |||| 0|eng d
020			_a9783319690421 _9
024	7		_a10.1007/978-3-319-69042-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQP552.H43 2018 EB
245	1	0	_aHeat Shock Proteins in the Immune System _cedited by Robert J. Binder, Pramod K. Srivastava.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (X, 185 páginas 22 ilustraciones,20 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
505	0		_aIntroduction and history.- Part I: Structure of the HSPs in relation to chaperoning peptides and proteins -- Chapter 1: Hsp70-subsrate interactions -- Chapter 2: Molecular Chaperone Inhibitors.- Part II: Exposure of HSPs to immune cells -- Chapter 3: Extracellular Heat Shock Proteins as Stress Communication Signals.- Part III: Regulation of immune responses by extracellular HSPs -- Chapter 4: The Heat Shock Protein-CD91 pathway and Tumor Immuno-surveillance -- Chapter 5: Bridging the gaps in the vaccine development: Avant-garde vaccine approach with secreted heat shock protein gp96-Ig -- Chapter 6: Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones -- Chapter 7: Heat shock protein mediated T cell responses in pathogen infections -- Chapter 8: An ancestral immune surveillance system in the amphibian Xenopus connecting certain heat shock proteins with classical and nonclassical MHC class I molecules -- Chapter 9: Inhibition of HSPs for Enhanced Immunity.     .
520	3		_aExperts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.  .
650		7	_aProteínas de choque térmico _2embne _9160151
650		7	_aInmunología _2embne _9138330
650		7	_aEnfermedades infecciosas _2embne _9138404
700	1		_aBinder, Robert J. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2018187807 _1http://viaf.org/viaf/8153833134764330186
700	1		_aSrivastava, Pramod K. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2018187808 _1http://viaf.org/viaf/14153833136064330198
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319690407
776	0	8	_iEdición impresa: _z9783319690414
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-69042-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b04/2019 _cm _dz _ek _feng _ggw _h0
999			_c100797 _d100797 _x1