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001			100793
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007			cr nn nnnaamaa
008			180803s2018 gw | s |||| 0|eng d
020			_a9783319893549 _9
024	7		_a10.1007/978-3-319-89354-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQH324.2 2018 EB
100	1		_aÁlvarez-Buylla Roces, María Elena _eautor. _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	0	_aModeling Methods for Medical Systems Biology : _bRegulatory Dynamics Underlying the Emergence of Disease Processes _cby María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XXI, 258 páginas 60 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1069
505	0		_aIntroduction -- Medical systems biology -- Modeling procedures -- Case of study -- Conclusions and Perspectives -- Bibliography.
520	3		_aThis book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.
650		7	_aBioinformática _2embne _9160489
650		7	_aGenética humana _2embne _9140562
700	1		_aMartínez-García, Juan Carlos _eautor. _4aut _4http://id.loc.gov/vocabulary/relators/aut
700	1		_aDávila-Velderrain, José _eautor. _4aut _4http://id.loc.gov/vocabulary/relators/aut
700	1		_aDomínguez-Hüttinger, Elisa _eautor. _4aut _4http://id.loc.gov/vocabulary/relators/aut
700	1		_aMartínez-Sánchez, Mariana Esther _eautor. _4aut _4http://id.loc.gov/vocabulary/relators/aut
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319893532
776	0	8	_iEdición impresa: _z9783319893556
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-89354-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b02/2019 _cm _dz _ea _feng _ggw _h0
999			_c100793 _d100793 _x1