000			04216nam a22003615i 4500
001			100787
003			ESmaUEC
005			20230102113011.0
006			a||||fo|||| 00| 0
007			cr nn nnnaamaa
008			180718s2018 gw | s |||| 0|eng d
020			_a9783319925073 _9
024	7		_a10.1007/978-3-319-92507-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aRF290 2018 EB
245	1	0	_aInflammatory Mechanisms in Mediating Hearing Loss _cedited by Vickram Ramkumar, Leonard P. Rybak.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (X, 231 páginas 39 ilustraciones,31 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
505	0		_aPreface -- The Cochlea -- Oxidative Stress and Hearing Loss -- Corticotropin Releasing Factor Signaling in the Mammalian Cochlea: An Integrative Niche for Cochlear Homeostatic Balance Against Noise -- Cochlear vascular pathology and hearing loss -- Cochlear Inflammation Associated with Noise-Exposure -- Middle Ear Infection and Hearing Loss -- Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss -- The Contribution of Anti-Oxidant and Anti-Inflammatory Functions of Adenosine A1 Receptor In Mediating Otoprotection -- Anti-inflammatory therapies for sensorineural hearing loss -- Implementation and Outcomes of Clinical Trials in Immune-Mediated Hearing Loss and other Rare Diseases -- Index.
520	3		_aThe primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation. Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be explained and molecular pathways leading to inflammatory processes will be outlined. Several different aspects of the cochlear inflammatory process will be discussed in detail. These include the sources of inflammatory cells, chemokines, inflammatory cytokines and the roles of cochlear resident immune cells in mediating hearing loss. In addition, evidence for a robust cochlear-based steroid axis which is activated by cochlear stress and serves a protective system. The role of the strial vasculature networks which aid in maintenance of the blood-labyrinth barrier and control the entry of circulating immune cells into the cochlea will be described. Molecular pathways leading to activation of the local inflammatory process will be highlighted and otoprotective treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-tympanic steroids and other drugs will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss. It is our hope that this book would provide a better understanding of the interaction of oxidative stress and inflammation in hearing loss. This book should provide basic information to scientists in the field of auditory research and to enlighten clinicians who treat patients with potentially ototoxic drugs.
650		7	_aAudición _xTrastornos _2embne _9168808
700	1		_aRamkumar, Vickram. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/nb2016003419 _1http://viaf.org/viaf/872145857115322921560
700	1		_aRybak, Leonard P. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n85162463 _1http://viaf.org/viaf/235398599
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319925066
776	0	8	_iEdición impresa: _z9783319925080
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-92507-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b03/2019 _cm _dz _ea _feng _ggw _h0
999			_c100787 _d100787 _x1