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020			_a9783319562346 _9
024	7		_a10.1007/978-3-319-56234-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aRA1211 2018 EB
245	0	0	_aChemical Mixtures and Combined Chemical and Nonchemical Stressors : _bExposure, Toxicity, Analysis, and Risk _cedited by Cynthia V. Rider, Jane Ellen Simmons.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XIV, 556 páginas 77 ilustraciones,54 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
505	0		_aIntroduction -- Combined exposures.-Measuring combined exposures -- Modeling complex exposures.-Prioritizing mixtures for study -- Environment-Wide Association Studies -- Biogeographical analysis of chemical co-occurrence -- Combining exposure and toxicity information to develop logical groupings for assessment -- Maximum Cumulative Ratio for deciding when to assess mixtures -- Establishing the "no interaction" baseline -- Dose addition models -- Response addition -- Integrated addition -- Mixture statistics - comparing predicted to observed -- Cumulative Risk Assessment -- Deciding which approach to use -- Component-based approaches -- Sufficient similarity of whole mixtures -- Other whole mixtures approaches -- Assessing interactions -- Likelihood and examples of chemical interactions -- PBPK modeling of chemical interactions -- Adding interactions to cumulative risk assessment -- Consideration of nonchemical stressors -- Toxicity and interactions of physical and chemical stressors -- Psychosocial and chemical stressors -- Adding nonchemical stressors to cumulative risk assessments -- Disease-based risk assessment -- Community-based risk assessment.
520	3		_aExposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are discussed, from initial-exposure characterization through the evaluation of risk associated with combined exposures. Several chapters also examine the adoption of promising tools from other disciplines. Looking beyond chemical mixtures, the discussion also addresses incorporating nonchemical stressors into toxicity studies and cumulative-risk assessments. This "excellent" volume-as described by Linda S. Birnbaum, Director of the National Institute of Environmental Health Sciences and the National Toxicology Program, in her foreword to the book-forms "a comprehensive picture of the current state of mixtures science." With contributions from a host of established experts, Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk is an essential text for mixtures researchers in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics. Both seasoned mixtures researchers and those new to the field will appreciate the clear explanations of mixtures concepts as well as the comprehensive presentation of available tools for predicting mixture effects and estimating risk from combined exposures. This volume also serves as a useful reference book for students. .
650		7	_aToxicología _2embne _9140328
650		7	_aProductos químicos _xEvaluación del riestos _2embne
700	1		_aRider, Cynthia V. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2018187982 _1http://viaf.org/viaf/12153953181005560226
700	1		_aSimmons, Jane Ellen. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2018187984 _1http://viaf.org/viaf/20153953185705560249
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319562322
776	0	8	_iEdición impresa: _z9783319562339
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-56234-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b07/2019 _cm _dz _ef _feng _ggw _h0
999			_c100779 _d100779 _x1