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008			180929s2018 gw | s |||| 0|eng d
020			_a9783319981642 _9
024	7		_a10.1007/978-3-319-98164-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQR395 2018 EB
100	1		_aIversen, Patrick L. _eautor _9669901
245	1	0	_aMolecular Basis of Resilience : _bAdapting to a Changing Environment _cby Patrick L. Iversen.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XIX, 312 páginas 11 ilustraciones,9 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
505	0		_aPrologue -- Preface -- Social Entropy -- Virus among Us -- Non-linear Anomalies -- Bacterial Infectious Disease -- Cure 2000 -- Chemicals in the Environment -- Immune Defense -- Metabolic Defense -- Analog Genetics -- Eteplirsen -- Regulating Resilience.
520	3		_aThis book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process. Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in "nonlinear anomalies." An example includes medical countermeasures for Ebola and Marburg viruses under the "Animal Rule." Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis ilustracionestrate how chemicals disrupt genomes. Historic research ignored RNA damage from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed. Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience. Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question "what informs molecular mechanisms of resilience?" that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience.
650		7	_aVirus ARN _9152632 _2embne
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319981635
776	0	8	_iEdición impresa: _z9783319981659
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-98164-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b07/2019 _cm _dz _ef _feng _ggw _h0
999			_c100770 _d100770 _x1