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008			180920s2018 gw | s |||| 0|eng d
020			_a9783319974217 _9
024	7		_a10.1007/978-3-319-97421-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQP114.C44 2018 EB
245	1	0	_aCardiac Extracellular Matrix : _bFundamental Science to Clinical Applications _cedited by Eric G. Schmuck, Peiman Hematti, Amish N. Raval.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XII, 246 páginas 35 ilustraciones,33 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1098
505	0		_aPreface -- Biomechanical Properties and Mechanobiology of Cardiac ECM -- Imaging the Cardiac Extracellular Matrix -- Animal Models and Cardiac Extracellular Matrix Research -- Applications of Cardiac Extracellular Ma-trix in Tissue Engineering and Regenera-tive Medicine -- Whole Cardiac Tissue Bioscaffolds -- Natural Sources of Extracellular Matrix for Cardiac Repair -- Cardiac Extracellular Matrix Modification as a Therapeutic Approach -- Extracellular Matrix for Myocardial Repair -- Role of Extracellular Matrix in Cardiac Cellular Therapies -- Regulation of Regenerative Medicine Products -- Clinical Trial Design for Investigational Cardio-Regenerative Therapy -- Regenerative Medicine Venturing at the University-Industry Boundary: Implications for Institutions, Entrepreneurs, and Industry -- Index.
520	3		_aThis book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM's role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.
650		7	_aCorazón _xEnfermedades _2embne _9169667
650		7	_aCitología _2embne _9139477
700	1		_aSchmuck, Eric G. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aHematti, Peiman. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/nb2013007587 _1http://viaf.org/viaf/295211428 _984638
700	1		_aRaval, Amish N. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319974200
776	0	8	_iEdición impresa: _z9783319974224
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-97421-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b04/2019 _cm _dz _ek _feng _ggw _h0
999			_c100755 _d100755 _x1