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008			180912s2018 gw | s |||| 0|eng d
020			_a9783319934853 _9
024	7		_a10.1007/978-3-319-93485-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQH588.S83 2018 EB
245	1	0	_aHuman Neural Stem Cells : _bFrom Generation to Differentiation and Application _cedited by Leonora Buzanska.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XI, 329 páginas 41 ilustraciones,40 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aResults and Problems in Cell Differentiation _x0080-1844 _v66
505	0		_aPart 1. Derivation and/or generation of human neural stem cells -- 1. Derivation of neural stem cells from the developing and adult human brain -- 2. Comparison of after-birth and adult somatic tissues in ability to generate human neural stem cells -- 3. Neural stem cells derived from human induced pluripotent stem cells and their use in models of CNS injury -- 4. Generation of human neural stem cells by direct phenotypic conversion -- Part 2. Differentiation and underlying mechanisms -- 5. Epigenetic regulation of human neural stem cell differentiation -- 6. Human iPSC-derived neuronal committed cells reveal common developmental genome deprograming in schizophrenia -- 7. Genome editing in human neural stem and progenitor cells -- 8. Brain Organoids - expanding our understanding of human development and disease -- 9. Microenvironmental cues in human neural stem cell fate commitment -- Part 3. Therapeutic potential of human neural stem cells -- 10. Updates on Human Neural Stem Cells: From Generation, Maintenance and Differentiation to Research and Translational Applications -- 11. Human neural stem cells for ischemic stroke treatment -- 12. Modeling pediatric and neuropsychiatric diseases using human iPSC -- 13. Neural stem cell dysfunction in human brain diseases -- 14. Human Fetal Neural Stem Cells for neurodegenerative disease treatment.
520	3		_aThis book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.
650		7	_aCélulas madre _2embne _9160528
650		7	_aNeurología _2embne _9139040
700	1		_aBuzanska, Leonora. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/nb2018020811 _1http://viaf.org/viaf/61154074435111741752
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319934846
776	0	8	_iEdición impresa: _z9783319934860
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-93485-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b04/2019 _cm _dz _ek _feng _ggw _h0
999			_c100747 _d100747 _x1