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024	7		_a10.1007/978-981-13-0719-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQH324.2 2018 EB
245	1	0	_aNon-coding RNAs in Complex Diseases : _bA Bioinformatics Perspective _cedited by Xia Li, Juan Xu, Yun Xiao, Shangwei Ning, Yunpeng Zhang.
264		1	_aSingapore _bSpringer International Publishing _c2018
300			_a1 recurso en línea (X, 126 páginas 42 ilustraciones,37 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1094
505	0		_a Chapter 1. Non-coding RNA resources -- Chapter 2. Systematic identification of non-coding RNAs -- Chapter 3. Functional characterization of non-coding RNAs through genomic data fusion -- Chapter 4. Genomic-scale prioritization of disease-related non-coding RNAs -- Chapter 5. Genome-wide mapping of SNPs in non-coding RNAs -- Chapter 6. Profiling DNA methylation patterns of non-coding RNAs (ncRNAs) in human disease -- Chapter 7. Aberrant epigenetic modifications of non-coding RNAs in human disease -- Chapter 8. Computationally modeling ncRNA-ncRNA crosstalk -- Chapter 9. Computational inferring of risk subpathways mediated by dysfunctional non-coding RNAs -- Chapter 10. Computational identification of cross-talking ceRNAs -- Chapter 11. Prediction of non-coding RNAs as drug targets -- Chapter 12. Methods for Identification of Protein-RNA interaction.
520	3		_aThis book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas. Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.
650		7	_aBioinformática _2embne _9160489
700	1		_aLi, Xia. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n82016077 _1http://viaf.org/viaf/56935191
700	1		_aXu, Juan. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/nr2003015999 _1http://viaf.org/viaf/313531112
700	1		_aXiao, Yun. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n88190184 _1http://viaf.org/viaf/55740506
700	1		_aNing, Shangwei. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aZhang, Yunpeng. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/no96006976 _1http://viaf.org/viaf/296681338
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9789811307188
776	0	8	_iEdición impresa: _z9789811307201
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-0719-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b03/2019 _cm _dz _ea _feng _ggw _h0
999			_c100739 _d100739 _x1