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008			180810s2018 gw | s |||| 0|eng d
020			_a9783319967042 _9
024	7		_a10.1007/978-3-319-96704-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQH634.2 2018 EB
245	1	0	_aEndocytosis and Signaling _cedited by Christophe Lamaze, Ian Prior.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (VIII, 329 páginas 28 ilustraciones,27 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aProgress in Molecular and Subcellular Biology _x0079-6484 _v57
505	0		_aPreface -- The endosomal network: mediators and regulators of endosome maturation -- Integration of the endocytic system into the network of cellular functions -- GTPases Rac1 and Ras signaling from endosomes -- ESCRT and membrane protein ubiquitination -- Retromer and it's role in regulating signaling at endosomes -- The lysosome and intracellular signaling -- Interplay of endocytosis and growth factor receptor signaling -- Role of the endocytosis of caveolae in intracellular signaling and metabolism -- EGFR trafficking in physiology and cancer -- Evolving view of membrane trafficking and signaling systems for G protein-coupled receptors -- Endosomal trafficking during mitosis and Notch-dependent asymmetric division.
520	3		_aThis book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks' output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms' development.
650		7	_aMembranas celulares _2embne _9142266
700	1		_aLamaze, Christophe. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/nb2018018235 _1http://viaf.org/viaf/188533224
700	1		_aPrior, Ian. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n86822419 _1http://viaf.org/viaf/201120738
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319967035
776	0	8	_iEdición impresa: _z9783319967059
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-96704-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b04/2019 _cm _dz _ek _feng _ggw _h0
999			_c100699 _d100699 _x1