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008			180801s2018 gw | s |||| 0|eng d
020			_a9783319935843 _9
024	7		_a10.1007/978-3-319-93584-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQP551 2018 EB
245	1	0	_aPrebiotic Chemistry and Chemical Evolution of Nucleic Acids _cedited by César Menor-Salván.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XVI, 291 páginas 113 ilustraciones,58 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aNucleic Acids and Molecular Biology, _x0933-1891 _v35
505	0		_a1. Nucleobases on the primitive Earth: their sources and stabilities -- 2. Condensation and decomposition of nucleotides in simulated hydrothermal fields -- 3. Mineral-Organic Interactions in Prebiotic Synthesis. The Discontinuous Synthesis Model for the Formation of RNA in Naturally Complex Geological Environments -- 4. From the dawn of Organic Chemistry to Astrobiology: urea as a foundational component in the origin of nucleobases and nucleotides -- 5. Searching for possible ancestors of RNA: The self-assembly hypothesis for the origin of proto-RNA -- 6. The origin of the ionized linker: Geochemical predestination for phosphate? -- 7. Template-directed replication of nucleic acids mediated by viscous environments -- 8. Folding and catalysis near life's origin: support for Fe2+ as a dominant divalent cation -- 9. Connections between mathematical models of prebiotic evolution and homochirality -- 10. Network theory in Prebiotic Evolution.
520	3		_aThe origin of life is one of the biggest unsolved scientific questions. This book deals with the formation and first steps of the chemical evolution of nucleic acids, including the chemical roots behind the origin of their components from the simplest sources in a geochemical context. Chemical evolution encompasses the chemical processes and interactions conducive to self-assembly and supramolecular organization, leading to an increase of complexity and the emergence of life. The book starts with a personal account of the pioneering work of Stanley Miller and Jeffrey Bada on the Chemistry of Origins of Life and how the development of organic chemistry beginning in the 19th century led to the emergence of the field of prebiotic chemistry, situated at the frontier between organic, geo- and biochemistry. It then continues reviewing in tutorial manner current central topics regarding the organization of nucleic acids: the origin of nucleobases and nucleosides, their phosphorylation and polymerization and ultimately, their self-assembly and supramolecular organization at the inception of life.
650		7	_9140525 _aÁcidos nucleicos _2embne
650		7	_aEvolución _2embne _9138470
700	1		_aMenor-Salván, César _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/nb2018018223
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319935836
776	0	8	_iEdición impresa: _z9783319935850
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-93584-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
998			_aSI _a_alco _a_vill _b02/2019 _cm _dz _ea _feng _ggw _h0
999			_c100688 _d100688 _x1