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001			100683
003			ESmaUEC
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007			cr nn nnnaamaa
008			180727s2018 gw | s |||| 0|eng d
020			_a9783319773094 _9
024	7		_a10.1007/978-3-319-77309-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQH591 2018 EB
245	1	0	_aNuclear-Cytoplasmic Transport _cedited by Weidong Yang.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (VI, 274 páginas 44 ilustraciones,40 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aNucleic Acids and Molecular Biology _x0933-1891 _v33
505	0		_aAssembly of the nuclear pore complex -- Structure of Yeast nuclear pore complexes -- Structure and function of nucleoporins in nuclear transport -- Dynamic structures of the nuclear pore complex and their roles in nucleo-cytoplasmic transport -- Non-canonical roles of nuclear pore proteins -- On the role of the channel nucleoporins in nuclear transport -- Structures of Importins and Exportins -- Navigating the Nuclear Envelope: one or multiple transport mechanisms for integral membrane proteins? -- mRNA export and its dysregulation in disease -- Coarse-grained molecular dynamics of the natively-unfolded domain of the NPC -- On the effects of leukemogenic nucleoporin fusion proteins on nucleocytoplasmic transport and gene expression -- Structure and Function of the Nuclear Pore Complex Revealed by Advanced Fluorescence Microscopy.
520	3		_aDysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
650		7	_aProtoplasma _9667591 _2embne
650		7	_aMicrobiología _2embne _9138684
700	1		_aYang, Weidong _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n87839570 _1http://viaf.org/viaf/46164277
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319773087
776	0	8	_iEdición impresa: _z9783319773100
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-77309-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
988			_aEBSPRINGER_2018
998			_aSI _a_alco _a_vill _b02/2019 _cm _dz _ek _feng _ggw _h0
999			_c100683 _d100683 _x1