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008			180720s2018 gw | s |||| 0|eng d
020			_a9783319895123
024	7		_a10.1007/978-3-319-89512-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQP517.C45 2018 EB
245	1	0	_aMolecular Mechanisms of Notch Signaling _cedited by Tilman Borggrefe, Benedetto Daniele Giaimo.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XXVII, 398 páginas 59 ilustraciones,56 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1066
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aIntroduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis -- Structural insights into Notch receptor-ligand interactions -- The Molecular Mechanism of Notch Activation -- Regulation of Notch Function by O-Glycosylation -- Modeling the Notch response -- Endocytic trafficking of the Notch receptor -- The Notch Interactome: complexity in signaling circuitry -- Integration of Drosophila and Human Genetics to understand Notch signaling related diseases -- Mechanisms of non-canonical signaling in health and disease: Diversity to take therapy up a Notch? -- The Notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms -- Notch and neurogenesis -- Notch and stem cells -- Oscillatory control of Notch signaling in development -- CSL-associated corepressor and coactivator complexes -- Notch and senescence -- Control of blood vessel formation by Notch signaling -- Notch and T cell function - a complex tale -- Notch in leukemia.
520	3		_aThis book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.
650		7	_aTransducción de la señal celular _2embne _9689361
700	1		_aBorggrefe, Tilman _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aGiaimo, Benedetto Daniele _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _9106996
776	0	8	_iEdición impresa: _z9783319895116
776	0	8	_iEdición impresa: _z9783319895130
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-89512-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc
988			_aEBSPRINGER_2018
998			_aSI _a_alco _a_vill _b02/2019 _cm _dz _ek _feng _ggw _h0