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008			181012s2018 si | s |||| 0|eng d
020			_a9789811313707 _9
024	7		_a10.1007/978-981-13-1370-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aRA1231.A5 2018 EB
245	1	0	_aNeurotoxicity of Aluminum _cedited by Qiao Niu.
264		1	_aSingapore _bSpringer International Publishing _c2018
300			_a1 recurso en línea (VII, 191 páginas 25 ilustraciones,13 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1091
505	0		_aOverview of the relationship between aluminum exposure and health of human being -- The Chemistry of Human Exposure to Aluminum -- Entry and Deposit of Aluminum in Brain -- Aluminum as a CNS and immune system toxin across the life span -- Occupational exposure to aluminum and cognitive impairment -- Exposure to aluminum in daily life and Alzheimer's disease -- Animal model of aluminum-induced Alzheimer's Disease -- Aluminum induced neural cells death -- Aluminum-induced electrophysiological variation, synaptic plasticity impairment and related mechanism -- Cross talk between Aluminum and genetic susceptibility and epigenetic modification in Alzheimer's disease.
520	3		_aThis book reviews the scientific literature and the authors' own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer's disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum's complex speciation chemistry in relation to biology, and details aluminum's mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal's debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity. .
650		7	_aAluminio _xToxicidad _9667664 _2embne
650		7	_aNeurobiología _2embne _9139039
700	1		_aNiu, Qiao _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9789811313691
776	0	8	_iEdición impresa: _z9789811313714
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-1370-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
988			_aEBSPRINGER_2018
998			_aSI _a_alco _a_vill _b02/2019 _cm _dz _ek _feng _ggw _h0
999			_c100664 _d100664 _x1