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008			181006s2018 gw | s |||| 0|eng d
020			_a9783319981468 _9
024	7		_a10.1007/978-3-319-98146-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aQH671 2018 EB
245	1	0	_aAutophagy in Health and Disease : _bPotential Therapeutic Approaches _cedited by Kursad Turksen.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XI, 177 páginas 28 ilustraciones,26 ilustraciones a color)
336			_aTexto _btxt _2rdacontent
347			_atext file _bPDF _2
490	0		_aStem Cell Biology and Regenerative Medicine _x2196-8985
505	0		_aAutophagy and Stem cells -- Fine-Tuning the Stem Cell Fate by Autophagy -- Role of Autophagy in Aging of Hematopoietic Stem Cells and Their Niche: Relevance in Clinical Transplantations and Regenerative Medicine -- Forkhead box O (FoxO) Transcription Factors in Autophagy, Metabolic Health, and Tissue Homeostasis -- The Role of mTOR in Osteoclasts -- Apoptotic Cell Clearance in Gut Tissue-Role of Intestinal Regeneration -- Autophagic Regulation of Cardiomyocyte Survival and Heart Regeneration -- The Role of Autophagy in Mesenchymal Stem Cell-Based Suppression of Immune Response -- Emerging Connections: Presynaptic Autophagy in Brain Aging and Neurodegenerative Diseases -- Virus and Autophagy: Enemies or Allies -- Cancer Stem Cells and Autophagy: Present Knowledge and Future Perspectives.
520	3		_aThis timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.
650		7	_aMuerte celular _2embne _9160237
650		7	_aFisiología celular _2embne _9165668
700	1		_aTurksen, Kursad _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/n2001009018 _1http://viaf.org/viaf/10099945 _984823
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319981451
776	0	8	_iEdición impresa: _z9783319981475
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-98146-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aBiomedical and Life Sciences (Springer-11642)
942			_2lcc
988			_aEBSPRINGER_2018
998			_aSI _a_alco _a_vill _b02/2019 _cm _dz _ek _feng _ggw _h0
999			_c100644 _d100644 _x1