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008			170929s2018 gw | fo |||| 0|eng d
020			_a9783662544693
024	7		_a10.1007/978-3-662-54469-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
041	0		_aeng
050		4	_aRD686 _b2018 EB
245		0	_aManagement of Periprosthetic Joint Infection : _bA global perspective on diagnosis, treatment options, prevention strategies and their economic impact _cedited by Klaus-Dieter Kühn
264		1	_aBerlin, Heidelberg _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XVIII, 366 páginas) _b196 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aMedicine (Springer-11650)
505	0		_aFrom the contents: 1. Introduction -- 2. Economic -- 3. Clinical Aspects -- 4. Diagnosis -- 5. Prevention -- 6. Treatment -- 7. ALBC -- 8. Spacer -- 9. Coating.
520	3		_aPeriprosthetic joint infection (PJI) is among the most serious complications in the field of endoprosthetics. The number of PJIs is increasing worldwide and poses a real interdisciplinary challenge for everyone involved. For the patient concerned, it is necessary to promptly work out an adequate therapy solution to fight off the infection. Both the clinical experience of the surgeon and the proper diagnostic processes are prerequisite for the reliable detection and identification of an infection. The microbiologist is responsible for identifying the causative germs by screening the patient's synovial fluid and tissue samples. Based on the findings and subsequent resistance testing, the infectious disease specialist can recommend the appropriate antibiotic therapy. Furthermore, the clinical pharmacist is consulted regularly throughout the therapy to discuss the risk of potential drug interactions. The surgeon will proceed with the revision surgery, following defined algorithms. Adequate radical debridement of infected and necrotic surrounding tissue is the most important step towards a successful cure of the infection. Accompanying the surgery, anti-infective agents are given systemically and locally. While systemic application of anti-infectives mainly reduces the number of haematogenic-spreading planktonic germs, local application immediately forms a colonization barrier and protects the implant from sessile biofilm formation. Concurrently, antibiotics are actively released from the implant, resulting in local germ reduction. Thus, local agents are embedded in the concept of surgical PJI treatment as a reliable adjuvant measure and they sustainably support the successful outcome. In one-stage procedures, local agents are released from specialized antibiotic-loaded bone cements, while in two- or multi-stage procedures, local agents are released from corresponding temporary spacers (interim prostheses). Even from an economic standpoint, the combination of systemic and local agent application is meaningful. Furthermore, there are some interesting trends towards the coating of metallic implants to protect against biofilm formation on the implant surface. On the basis of their personal experience, specialists from all over the world present, explain and discuss preventive approaches, appropriate diagnostic strategies for detection, reproducible effective surgical treatments  as well as the economic impact of PJI. The reader can use this book as a solid platform for comparing their own approach to PJI treatment with the specialists' recommendations.  .
988			_aSpringer_Medicine_2018
650		7	_2embne _9191993 _aArticulaciones _xPrótesis
650		7	_2embne _9269140 _aArticulaciones _xInfecciones
700	1		_aKühn, Klaus-Dieter. _eeditor literario
776	0	8	_iEdición impresa: _z9783662544686
776	0	8	_iEdición impresa: _z9783662544709
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-662-54469-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b04/2020 _dz _eb _zSI