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008			180102s2018 si | s |||| 0|eng d
020			_a9789811065804 _9
024	7		_a10.1007/978-981-10-6580-4 _2doi
040			_aES-MaUEC _bspa
050		4	_aRC537 2018 EB
245	1	0	_aUnderstanding Depression: _bVolume 1. Biomedical and Neurobiological Background _cedited by Yong-Ku Kim.
264		1	_aSingapore _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XIII, 322 páginas 16 ilustraciones, 14 ilustraciones a color)
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
505	0		_a1.Genetic and epigenetic aspects of depression -- 1-1.Highlights on pharmacogenetics and pharmacogenomics in depression -- 1-2.Imaging genetics studies on susceptibility genes for major depressive disorder: the present and the future -- 1-3.Gene-environmental interaction and role of epigenetic in depression -- 1-4.The role of microRNAs and long noncoding RNAs in depression: diagnosis and therapeutic implication -- 1-5.The role of early life stress in HPA axis and depression -- 2.Molecular-, cellular-level aspects of depression -- 2-1.Complex role of serotonin receptors in depression -- 2-2.Emerging role of glutamate receptors in pathophysiology of depression -- 2-3.New perspective on mTOR pathways: a new target of depression -- 2-4.Cellular aging in depression: the role of telomere-telomerase system -- 2-5.Differentiation and biological markers in subtype of depression -- 3.Neural circuit-level aspect of depression -- 3-1.Molecular, structural, and functional neuroimaging in depression -- 3-2.Resting-state activity in depression; a link to spatiotemporal psychopathology -- 3-3.Functional neuroimaging in depression: a tool to predict treatment outcome and response -- 3-4.Cortical-subcortical interactions in the pathophysiology of depression -- 3-5.Pathophysiology and treatment strategies for different types of depression -- 3-6.The effect of neurostimulation in depression -- 4.Multicellular system-level aspect of depression -- 4-1.Inflammation, depression and neurodegeneration: a possible cause of dementia in late life depression? -- 4-2.Gut-microbiota-brain axis and depression -- 4-3.The interactions of immune inflammation and oxidative and nitrosative stress with the kynurenine and melatonergic pathways in depression -- 4-4.Glia-neuron cross-talk in depression -- 4-5.Depression model in primate: relevance to novel drug discovery -- 5.Species-, individual-, gender-, culture-specific aspects of depression -- 5-1.Precision psychiatry: personalized clinical approach to depression -- 5-2.Gender differences in depression -- 5-3.An up-date on the epidemiology of major depressive disorder across cultures.
520	3		_aThis book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression. The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.
650		7	_aPsiquiatría _2embne _9139041
650		7	_aNeurología _2embne _9139040
650		7	_aNeurociencias _2embne _9158907
700	1		_aKim, Yong-Ku. _eeditor literario _0http://id.loc.gov/authorities/names/n2017073847 _0http://viaf.org/viaf/118151352055352602259
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _0http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9789811065798
776	0	8	_iEdición impresa: _z9789811065811
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-10-6580-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aMedicine (Springer-11650)
988			_aSpringer_Medicine_2018
998			_b02/2019 _dz _ep _feng _ggw _h0
999			_c100342 _d100342 _x1