000			03337nam a22003975i 4500
001			100273
003			DE-He213
005			20230110040211.0
007			cr nn 008mamaa
008			171121s2018 gw | s |||| 0|eng d
020			_a9783319434865 _9
024	7		_a10.1007/978-3-319-43486-5 _2doi
040			_aES-MaUEC _bspa
050		4	_aRC271.I45 _bI468 2018 EB
245	0	0	_aImmunotherapy for Pediatric Malignancies _cedited by Juliet C. Gray, Aurélien Marabelle.
264		1	_aCham _bSpringer International Publishing _c2018
300			_a1 recurso en línea (IX, 297 páginas 29 ilustraciones, 27 ilustraciones a color)
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
505	0		_aIntroduction to Pediatric Cancer Immunotherapy -- Overcoming immune suppression in the tumor microenvironment: Implications for multi-modal therapy -- Allogeneic stem cell transplantation -- Overview of monoclonal antibody therapies -- Monoclonal Antibodies Targeting Hematological Malignancies -- Monoclonal Antibodies Directly Targeting Antigens on Solid Tumours -- Monoclonal antibodies targeting the immune system -- Adoptive T Cell Therapies for Children's Cancers -- NK Cell and NKT Cell Immunotherapy -- Cancer Vaccines in Pediatrics -- Immune Adjuvants and Cytokine Therapies -- Immune biomarkers in pediatric malignancies -- Future perspectives.
520	3		_aThis book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy. Edited by two distinguished pediatric oncologists with a collection of chapters from the most authoritative experts in cancer immunotherapy, this is an indispensable volume for pediatric oncologists and physicians working in childhood cancer care.
650		7	_aOncología _2embne _9139207
650		7	_aCáncer en niños _2embne _9157453
650		7	_aImmunoterapia _2embne
700	1		_aGray, Juliet C. _eeditor literario _0http://viaf.org/viaf/16151963695500312714
700	1		_aMarabelle, Aurélien. _eeditor literario
776	0	8	_iEdición impresa: _z9783319434841
776	0	8	_iEdición impresa: _z9783319434858
776	0	8	_iEdición impresa: _z9783319828374
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-43486-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aMedicine (Springer-11650)
988			_aSpringer_Medicine_2018
998			_b01/2019 _dz _ea _feng _ggw _h0
999			_c100273 _d100273 _x1