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008			180305s2018 gw | fo |||| 0|eng d
020			_a9783319718156
024	7		_a10.1007/978-3-319-71815-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
041	0		_aeng
050		4	_aQH465.A1 _b2018 EB
245	0	2	_aA Clinician's Guide to Sperm DNA and Chromatin Damage _cedited by Armand Zini, Ashok Agarwal
264		1	_aCham _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XIX, 605 páginas)
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aMedicine (Springer-11650)
520	3		_aThis comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male .
988			_aSpringer_Medicine_2018
650		7	_2embne _9156720 _aMutagénesis
650		7	_2embne _aReproducción humana _9150790
650		7	_2embne _9144875 _aMutación (Biología)
700	1		_aZini, Armand. _eeditor literario _0http://id.loc.gov/authorities/names/n2011185005 _0http://viaf.org/viaf/210984685
700	1		_aAgarwal, Ashok _eeditor literario _0http://id.loc.gov/authorities/names/nb2011002412 _0http://viaf.org/viaf/165944699 _985093
776	0	8	_iEdición impresa: _z9783319718149
776	0	8	_iEdición impresa: _z9783319718163
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-71815-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b04/2020 _dz _eb _zSI