000			03861nam a22003855i 4500
001			100021
003			DE-He213
005			20230110040201.0
007			cr nn 008mamaa
008			180524s2018 xxu| s |||| 0|eng d
020			_a9781493977840 _9
024	7		_a10.1007/978-1-4939-7784-0 _2doi
040			_aES-MaUEC _bspa
050		4	_aRC902 2018 EB
245	1	0	_aPolycystic Kidney Disease: _bTranslating Mechanisms into Therapy _cedited by Benjamin D. Cowley, Jr., John J. Bissler.
264		1	_aNew York _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XIII, 273 páginas 62 ilustraciones, 42 ilustraciones a color)
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
505	0		_aPART 1. POLYCYSTIC KIDNEY DISEASE GENES & PROTEINS -- 1. Classical Polycystic Kidney Disease (PKD): Gene Structures and Mutations and Protein Structures and Functions -- 2. Bardet-Biedl Syndrome -- 3. Cystic Kidney Diseases Associated with Increased Cancer Risk: Tuberous Sclerosis Complex, Von Hippel Lindau, and Birt Hogg Dubé -- PART 2. POLYCYCSTIC KIDNEY DISEASE: MECHANISMS OF DISEASE -- 4. Aberrant Cellular Pathways in PKD -- 5. Cilia and Polycystic Kidney Disease -- 6. The Role of Inflammation and Fibrosis in Cystic Kidney Disease -- PART 3. CLINICAL FEATURES -- 7. Imaging-based Diagnosis of Autosomal Dominant Polycystic Kidney Disease -- 8. Renal Structural Involvement in Autosomal Dominant Polycystic Kidney Disease: Cyst Growth and Total Kidney Volume: Lessons from the Consortium for Radiologic Imaging of Polycystic Kidney Disease (CRISP) -- 9. Renal Complications: Pain, Infection and Nephrolithiasis -- 10. ADPKD Extrarenal Manifestations: Polycystic Liver Disease -- 11. Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease -- PART 4. CLINICAL TRIALS AND EMERGING THERAPIES -- 12. Role of Renin- Angiotensin- Aldosterone System Inhibition in Autosomal Dominant Polycystic Kidney Disease -- 13. Vasopressin Receptor Antagonism -- 14. End-stage Renal Disease in Patients with Autosomal Dominant Polycystic Kidney Disease -- 15. Polycystic Kidney Disease: Translating Mechanisms into Therapy Management of ADPKD Today.
520	3		_aThis comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD's clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.
650		7	_aRiñones _xEnfermedades _9168885 _2embne
650		7	_aNefrología _2embne _9143254
700	1		_aCowley, Jr., Benjamin D _eeditor literario
700	1		_aBissler, John J _eeditor literario _0http://id.loc.gov/authorities/names/n2018188132 _0http://viaf.org/viaf/12154074360611740705
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _0http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9781493977826
776	0	8	_iEdición impresa: _z9781493977833
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-7784-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
490	0		_aMedicine (Springer-11650)
988			_aSpringer_Medicine_2018
998			_b02/2019 _dz _ef _feng _ggw _h0
999			_c100021 _d100021 _x1