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Preface; Contents; Chapter 1: The Extracellular Matrix of Tumors: A Focus on Fibronectin and Fibulin-5; 1.1 The Function and Composition of the Extracellular Matrix; 1.2 The Role of the ECM in Tumor Development with Emphasis on FN; 1.3 Matricellular Proteins: Extracellular Modulators of the ECM; 1.4 Fibulin-5; 1.4.1 Fbln5 in Cell Adhesion/Migration; 1.4.2 Fbln5 in Proliferation/Survival; 1.4.3 Fbln5 in Angiogenesis; 1.4.4 Fbln5 in Tumor Progression; 1.5 Conclusion; References; Chapter 2: Internalization of Collagen: An Important Matrix Turnover Pathway in Cancer

2.1 Collagen Degradation in Cancer2.2 Extracellular Collagen Degradation; 2.3 Intracellular Collagen Degradation; 2.3.1 The Collagen Internalization Receptor uPARAP/Endo180; 2.3.2 The Collagen Internalization Receptor MR; 2.4 Intracellular Collagen Degradation In Vivo; 2.4.1 Imaging Collagen Internalization In Vivo; 2.4.2 Intracellular Collagen Degradation in Cancer; References; Chapter 3: Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression; 3.1 Structure, Function, and Regulation of Lumican; 3.2 Lumican Implications in Cancer; 3.2.1 Breast Cancer

3.2.2 Colorectal Cancer3.2.3 Lung Cancer; 3.2.4 Pancreatic Cancer; 3.3 Drug Delivery in Cancer and Its Association with Lumican Expression; 3.3.1 Collagen Organization in Tumors; 3.3.2 VEGF and PDGF; 3.4 Summary; References; Chapter 4: Versican: Role in Cancer Tumorigenesis; 4.1 Introduction; 4.2 Source of Versican in Cancer; 4.3 The Role of Versican in Cancer; 4.4 The Regulation of Versican Expression in Cancer; 4.5 Versican as a Diagnostic and Prognostic Marker in Cancer; 4.6 Versican in LMS: Our Experience; 4.7 Conclusions; References

6.2.1 Transcription Factors Promoting Invasion6.2.2 Establishing the Invasive Cell Membrane; 6.2.3 AC Invadopodia and the Invasive Protrusion: Breaching and Clearing the BM; 6.3 Post AC Invasion: BM Sliding Further Opens the Breach; 6.4 AC Invasion and SPARC: A Model for the Tumor Microenvironment; 6.5 Summary and Perspective; References

Chapter 5: Engineering Advanced Models of the Glioblastoma Microenvironment Using Biomaterials5.1 Introduction; 5.2 The Role of the Microenvironment in GBM Malignancy; 5.2.1 ECM; 5.3 Engineering Advanced Models of the GBM Microenvironment; 5.3.1 Traditional Culture Systems; 5.3.2 Polymer-Based 3D Matrices; 5.3.3 Microfabricated Platforms; 5.3.4 Molecular Discovery and Screening; 5.4 Future Directions; 5.5 Conclusions; References; Chapter 6: Breaching and Opening Basement Membrane Barriers: The Anchor Cell Leads the Way; 6.1 Introduction; 6.2 Breaching the BM De Novo: AC Invasion

This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.