Incluye referencias bibliográficas e índice

880-01 Foreword; Preface; Contents; Contributors; 1: The Rising Incidence of Thyroid Cancer: Contributions from Healthcare Practice and Biologic Risk Factors; Introduction; Incidence of Thyroid Cancer; Increased Detection of Subclinical Disease; Biologic Risk Factors for Thyroid Cancer; Ionizing Radiation as a Risk Factor for Thyroid Cancer; Obesity, Estrogen, and the Metabolic Syndrome; Other Proposed Modulators of Thyroid-Stimulating Hormone and Thyroid Cancer Risk; References; 2: Molecular Genetics of Thyroid Cancer; Papillary Thyroid Cancer; BRAF; Genetics.

Gene Mutation Panels Test Characteristics; Clinical Validity; Clinical Utility; Clinical Applicability; Future Horizons; Next-Generation Sequence Panel; Test Characteristics; Clinical Validity; Clinical Utility; Future Directions; References; 6: Clinical Presentation and Diagnosis of Papillary Thyroid Cancer; Introduction; The Incidence of Thyroid Cancer Is Rising; What Are the Risk Factors for Developing PTC?; Demographics and Epidemiology of Thyroid Cancer; Family History; Radiation History; Nodular Goiter; Evaluation of Patients with a Thyroid Nodule.

Indication for Biopsy Pathology Reporting; References; 4: Pathologic Diagnosis of Thyroid Cancer; Introduction; Specimen Acquisition and Slide Preparation; Terminology for Reporting Thyroid Fine-Needle Aspiration; Class I: Nondiagnostic or Unsatisfactory; Class II: Benign; Class III: Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance; Class IV: Follicular Neoplasm or Suspicious for Follicular Neoplasm; Class V: Suspicious for Malignancy; Class IV: Malignant; Core-Needle Biopsy; The Role of Frozen Section Examination in Thyroid Disease.

Surgical Pathology of Differentiated Thyroid Cancers Papillary Thyroid Carcinoma; FNA; Gross Examination; Microscopic Features; PTC Variants; Follicular Thyroid Carcinoma; Gross Examination; Microscopic Features; FTC Subtyping; Pitfalls; Limitations of FNA; Hyalinizing Trabecular Tumor; Thyroiditis; Intrathyroidal Parathyroid; Endocrine Atypia; References; 5: Molecular Diagnostic Approaches and Their Clinical Utility; Introduction; Afirma Gene Expression Classifier (GEC); Test Characteristics; Clinical Validity; Clinical Applicability; Future Direction.

This text provides a comprehensive, state-of-the art review of this field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in thyroid cancer. The book reviews new data about molecular genetics and molecular diagnostic approaches, covers diagnosis and treatment of localized disease, and conventional and newer therapies for dealing with recurrent and metastatic disease. Areas of controversy, with expert opinions from both outlooks, are also covered. Management of Differentiated Thyroid Cancer serves as a very useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information.