Foreword; Preface; Contents; Contributors; 1: Overview of€Hematopoietic Cell Transplantation; Historical Perspective; Indications for€Allogeneic Hematopoietic Cell Transplantation; Sources of€Hematopoietic Stem Cells; Peripheral Blood Mobilized Stem Cells; Bone Marrow Hematopoietic Stem Cells; Umbilical Cord Blood Stem Cells; Stem Cell Donors; Matched Related Donor; Matched Unrelated Donor; Haploidentical Stem Cell Donors; Conditioning Regimens; Myeloablative Regimens; Reduced-Intensity Conditioning; Graft-Versus-Host Disease Prophylaxis and€Treatment; Prophylaxis.

6: Grading and€Treatment of€Acute Graft-ƯVersus-ƯHost Disease Diagnosis and€Grading of€aGVHD; Physiology Overview; Diagnosis; Differential Diagnosis; Drug Hypersensitivity; Toxic Erythema of€Chemotherapy; Engraftment Syndrome; Grading and€Prognostication; Treatment of€aGVHD; Brief Note on€the€Prevention of€aGVHD; Treatment of€Grade I€aGVHD; Grade II or Greater aGVHD; Corticosteroid-Refractory aGVHD; Extracorporeal Photopheresis; Anti-CD26 Antibody; Rabbit Antithymocyte Globulin; References.

Histologic Grading and€Microscopic Findings Clues to€Histologic Diagnosis; Differential Diagnosis of€Acute GVHD; Potential Adjunctive Tests; Special Situations; Chronic Graft-Versus-Host-Disease; Main Histologic Patterns in€cGVHD: Lichenoid and€Sclerodermoid; Unique Histologic Features of€cGVHD; Psoriasiform Pattern; Eczematous Pattern; Lupus-like Pattern; Pityriasis Rosea-like Pattern; Comedone-like Pattern; Follicular Keratosis or Keratosis Pilaris-like Pattern; cGVHD-associated Angiomatosis; Differential Diagnosis of€cGVHD; References.

Inflammatory Cytokine Biomarkers Genetic Polymorphism; References; 3: Clinical Presentation of€Acute Cutaneous Graft-Versus-Host Disease; Diagnosing and€Staging/Grading Acute€GVHD; Clinical Manifestations of€Acute GVHD; Erythema; Follicular Accentuation; Morbilliform Lesions; Erythroderma; Reticulated Patterns; Desquamation; Bullae; Papules; References; 4: Clinical Presentation of€Mucosal Acute and€Chronic Graft-Versus-Host Disease; References; 5: Histopathology of€Cutaneous Graft-ƯVersus-ƯHost Disease; Acute Graft-Versus-Host Disease; Concept of€Interface Dermatitis.

Treatment of€Acute GVHD Chronic GVHD; Risk Factors Associated with€Chronic GVHD; Treatment of€Chronic GVHD; Causes of€Treatment Failure; Supportive Care; References; 2: Pathophysiology and€Immunology of€Chronic Graft-Versus-Host Disease; Basic Biology of€cGVHD; cGVHD Biomarker; Cellular Biomarkers; T Cells; T-Cell Differentiation Status; CD4 T-Cell Cytokine Subsets (Th1, Th2, Th 17); Regulatory T Cells (Tregs); Antigen-Presenting Cells; B Cells and€Humoral Immunity; B Cell and€B-Cell Activating Factor (BAFF); Auto-antibodies; Allo-antibodies; Natural Killer (NK) Cells.

This atlas provides valuable guidance for medical students, residents, fellows, nurses, attending physicians, and other allied health professionals taking care of patients with graft-versus-host disease (GVHD). Our understanding about the intricacies of GVHD diagnosis and treatment are constantly developing as basic and translational science in the field evolves. As such, this text reflects the best current evidence we have to date for clinicians treating patients with GVHD. The Atlas of Graft-versus-Host Disease is a concise and useful graphical resource providing comprehensive guidance required for a disease entity that has a heterogeneous and complicated clinical presentation. It has been written with input of both oncologists and dermatologists, which has enabled the capture of perspectives and nuances of GVHD diagnosis and management that can influence readers with varied training backgrounds and current clinical practice, thus creating a powerful and useful resource for readers.