Historical Perspective on the Classification and Nomenclature of Pulmonary Hypertension -- The Defining Characteristics of Pulmonary Arterial Hypertension -- Pulmonary Hypertension in Patients Without Pulmonary Arterial Hypertension -- Epidemiology of Pulmonary Hypertension: From Quaternary Referral Centre to the Community -- The Effects of Chronic Hypoxia on Inflammation and Pulmonary Vascular Function -- Genetics of Pulmonary Vascular Disease -- Novel Mechanisms of Disease: Network Biology and MicroRNA Signaling in Pulmonary Hypertension -- Pulmonary Hypertension as a Metabolic Disease -- Renin-Angiotensin-Aldosterone and other Neurohumoral Factors in the Pathogenesis of Pulmonary Hypertension -- Animal Models of Pulmonary Hypertension -- The Cardiopulmonary Hemodynamic Evaluation of Pulmonary Hypertension -- Advanced Imaging in Pulmonary Hypertension -- Assessing Disease State in the Pulmonary Vasculature in Clinical Practice and Research -- Biomarkers and other Methods for Assessing Patient Progress -- Pulmonary Circulatory - Right Ventricular Uncoupling: New Insights into Pulmonary Hypertension Pathophysiology -- Contemporary Pharmacotherapies Involving Nitric Oxide, Prostacyclin, and Endothelin Receptor Signaling Pathways -- Determining the Optimal Approach to Initiating Oral, Inhaled, and Intravenous Therapies in Clinical Practice: Sequential Goal-Directed Therapy is Best -- Counterpoint: Determining the optimal approach to initiating oral, inhaled, and intravenous therapies in clinical practice: Maximal upfront therapy is best -- Surgery, Devices, Transplantation and Other Interventional Options for the Treatment of Advanced Pulmonary Hypertension -- Patient Registries in Pulmonary Arterial Hypertension:� the Role of Survival Equations and Risk Calculators -- Support Care for the Pulmonary Hypertension Patient -- Special Considerations for the Pulmonary Hypertension Patient -- The Future of Pulmonary Hypertension.

This definitive textbook details the rapid advances in epidemiology, pathobiology and therapeutics in the field of pulmonary hypertension. Despite recent progress, under-awareness persists within the practicing pulmonary, cardiovascular, and general internal medicine communities. This is due, in part, to the complex array of molecular mechanisms implicated in the pathobiology of PH, as well as cutting-edge discoveries from translational scientific works that provide a new framework by which to understand pulmonary vascular-right ventricular coupling.�This book bridges this knowledge gap through the synthesis of a contemporary text that emphasizes basic science, translational and clinical principles, and treatment strategies for understanding pulmonary hypertension. Pulmonary Hypertension: Basic Science to Clinical Medicine is the essential reference for any physician or scientist with an interest in pulmonary hypertension. The Editors and their hugely knowledgeable list of contributors have provided a contemporary, comprehensive overview of the field in all of its complexity that will be vital for all levels of clinician, researcher and trainee in respiratory medicine, cardiology, critical care and all disciplines involved in the management of patients with pulmonary hypertension.