Part I. Introduction to Drug-Drug Interactions -- 1. Letâ€{u3813}tart at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug-Drug Interactions -- 2. Pharmacodynamic Interactions:Âïre Concepts -- 3. Pharmacokinetic Interactions:Âïre Concepts -- 4. A Brief Treatise On The Area Under The Curve -- Part II. Introduction to Drug-Drug Interactions:²ief Review of CYP450 Enzymes, UGTs, and Transporters -- 5. CYP2D6:Âרere It All Began -- 6. CYP2E1:The Anesthesia Enzyme -- 7. CYP3A4:The Workhorse -- 8. CYP1A2:The Switch-hitter -- 9. CYP2B:Â{u2820} 2B or Not 2B?- 10. CYP2C9:The Support Crew I -- 11. CYP2C19:Â{u2820} The Support Crew II -- 12. UGTs:Âïnjugating Cousins -- 13. The Cytochrome P450 System In Disease Statesâ€{u1802}rief Review -- PART III. Drug-Drug Interactions:ÂСradigms and Core Concepts -- 14. P-glycoprotein and OATP Transporters -- 15. TheÂ{u0880}œFatalâ€Ưrty -- 16. The Six Patterns of Pharmacokinetic Drug-Drug Interactions -- 17. The Problem with the Drug-Drug Interaction Software: A Procrustean Dilemma -- 18. Pharmacogenomics -- 19. The Pharmacoepidemiology of Drug Interactions: Why and How They Are Important -- 20. The Lawyers Can Read, Too:Âáse Presentations from the Courtroom -- Part IV. Drug-Drug Interactions Involving Inhalational Anesthetic Agents -- 21. Introduction -- 22. That Sums It Up -- 23. 1+1+1+1=? -- 24. A Delayed Surgeon Is A “Dismayedâ€{u04F5}rgeon? -- 25. Relax, Itâ€{u380F}nly Gentamicin -- 26. Jaundice After Surgery -- 27. Everybody Clear? -- 28. The Hemodynamic Hole -- 29. Alpha-2 To The Rescue But Beware Bradycardia -- 30. Hot Stuff! -- Part V. Drug-Drug Interactions Involving Intravenous Anesthetic Agents -- 31. Introduction -- 32. How to Successfully Occlude an Intravenous Line -- 33. A Curious Cause of Seizures -- 34. Magnesium Mama And The Mad Dad -- 35. Dexyâ€{u380D}idnight Spinal -- Part VI. Drug-Drug Interactions Involving Local Anesthetics -- 36. Introduction -- 37. Comfortably Numb -- 38. Naturally Occurring And Nasty -- 39. LOL-LOL:Â{u0329}ttle Old Ladyâ€{uCBF4}s of Lido -- 40. The Spinal Countdown -- 41.Â{u0072}e Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity?Â{u04ED}oking Gun I -- 42. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity?Â{u04ED}oking Gun II -- 43. A Perfect Storm? -- 44. Shake Rattle and Roll -- 45. Hello, We Have A Patient With Acute Delirium and We Need An Urgent Psych Consult -- 46. Fatal Pain Relief -- 47. Lipid Lifesaver -- Part VII. Drug-Drug Interactions Involving Opioids -- 48. Introduction -- 49. No â€S̃ubsâ€{u4A74}ute for Sobriety -- 50. A Needle And The Damage Done -- 51. Dadâ€{u380E}ot Having Much Pain -- 52. Royal Flush -- 53. The Worry Thatâ€{u3801}lways With Us:Â{u0066}ternoon Nap -- 54. The Bawling Baby -- 55. Sleeping Beauty -- 56. Codeine Canâ€{u4804}o It -- 57. A Shuddering Interaction -- 58. Double Indemnity -- 59. Breaking the Codeine -- 60. The Ultimate Ultram Primer I:Â{u0379} Mood Is Better, But Boy Do I Hurt! -- 61. The Ultimate Ultram Primer II: I “Haightâ€Urcotics But I Hate Seizures Worse -- 62. The Ultimate Ultram Primer III:Â{u0532}emor-dol Trigger in Serotonin Syndrome -- 63. Too Much of A Good Thing -- Part VIII. Drug-Drug Interactions Involving Non-opioid Pain Medications -- 64. Introduction -- 65. Pining For Pete In The Pain Clinic -- 66. You Do Not Look Well Today, Mon Ami -- 67. My Headache is Gone, But My Leg Now Hurts -- 68. Special â€K̃â€{u1CE5} -- 69. Not Manic About NSAIDs -- 70. Keep It Capped! -- 71. The ACE Is Not Always High -- 72. When The Smoke Clears, Relaxation Disappears -- 73. Befuddled by Aspirin -- 74. You Canâ€{u4814}rick Us! -- Part IX. Drug-Drug Interactions Involving Benzodiazepines and Other Sedatives -- 75. Introduction -- 76. The Worry Thatâ€{u3801}lways With Us:Â{u03AF}w Iâ€{uD804}epressed -- 77. The Worry Thatâ€{u3801}lways With Us: Tragic But Not Rare -- 78. Lack of Sedation -- 79. A Cold Isnâ€{u4807}oing to Slow Me Down -- 80. Her Patients Never Wake Up On Time -- 81. When Enough Is Now Too Much -- 82. The Distressed Daughter -- 83. Check Check and Double Check -- 84. Doggone Itâ€{u4A25} Case is Cancelled -- 85. Noctâ€{u03F5}t -- 86. Predisposed to Doze -- 87. Synergistic Sedation -- Part X. Drug-Drug Interactions Involving Neuromuscular Blockade Agents -- 88. Introduction -- 89. Blocked Again -- 90. Irreversibility Sux -- 91. Keep An “Ionâ€{u0528}e Twitches -- 92. A Reversal of Misfortune -- 93. Stop Moving -- 94. Thereâ€{u380A}ust Not Enough Roc In The World -- 95. Slow Sux I:Â{u0060}Lengthy Wake-Up Period After Electroconvulsive Therapy -- 96. Slow Sux II:Â{u0260}Remember Reviewing This For The Boards -- 97. Slow Sux III:Âרere Did the Twitches Go? -- 98. Weakened All Weekend -- 99. The Patient Who Could Not Raise Her Head -- 100. An Unexpected Wait -- 101. Diabolical Cough Syrup -- Part XI. Drug-Drug Interactions Involving Antibiotics and Antifungals -- 102. Introduction -- 103. Full Stop -- 104. Flummoxed by the FLOX -- 105. Tales of Terror -- 106. Too Low To Go -- 107. A Fungal Story -- 108. Rejection Protection Turned Kidney Killer -- 109. Canâ€{u4807}et Well -- 110. Linezolid (I): Be VREy Careful -- 111. Linezolid (II):Â{u0239}per and Hot -- 112. Not Sweet At All -- 113. Where Did All The Sugar Go? -- 114. Exposed! (Part 1) -- 115. Exposed! (Part 2) -- 116. Seizures on 5 West -- Part XII. Drug-Drug Interactions Involving Cardiovascular Medications -- 117. Introduction -- 118. Riding The Rollercoaster -- 119. A Pressing Need For Vasopressin! -- 120. Too Young To Die -- 121. A Widening Gyre -- 122. Misusing Momâ€{u380D}eds -- 123. If the Patient Has No Renal Failure, Why is Her Potassium So High? -- 124. Prazosin and the PTSD Paratrooper -- 125. Nicardipine Notes -- 126. Hypotension Harry -- 127. Too Slow to Flow -- 128. Better Sleep But Slower Heart -- 129. Extreme Blood Pressure After Ephedrine:Â{u04E8}ould We Rule Out Pheochromocytoma? -- 130. Heart-Stopping Treatment -- 131. Induction Crashes:Â{u0072}e There Clues In the Ashes? -- 132. The Wakeup Call: 2AM Trauma -- 133.Âơlling Down -- 134. A Hidden Drug -- 135. Iâ€{uD80C}istening, Iâ€{uD80C}istening -- 136. Jump Start My Heart -- 137. The Statin Trilogy (I): â€S̃tatinâ€{u01B2}om The Beginning -- 138. The Statin Trilogy (II): Tripped And Fell At The Train â€S̃tatinâ€{u0B6D} 139. The Statin Trilogy (III): Welcome To The United â€S̃tatinsâ€{u03E6} America -- 140. Be Still, My Beating Heart -- 141. The Nice Niece -- 142. Cyclo Killer: Quâ€{u5CF4}-ce que câ€{u5CF4}? -- 143. Blurry-Eyed With Rapid Heart Beats -- Part XIII. Drug-Drug Interactions Involving Coagulation Modifiers -- 144. Introduction -- 145. Seize the Day -- 146. The Third and Final Complication -- 147. An Interaction With the Furniture -- 148. Macrolide Mishap for Little Miss Muffett -- 149. From Asymptomatic to Symptomatic:Â{u0860}Cause of Nosebleed -- 150. The Consequences of Not Following A Cardiac Diet -- 151. Clopidogrel (I):¡gel Brunch -- 152. Clopidogrel (II):Âïnferring Over The Kung Pao -- Part XIV. Drug-Drug Interactions Involving Immunosuppressants, Antiemetics, and Chemotherapy -- 153. Introduction -- 154. Beaned -- 155. Addisonian Adjustment -- 156. Tea Time -- 157.Â{u03AF} Fits at Uffizi -- 158. Quit Steroids Quit Kidneys -- 159. The Fall Guy (I) -- 160. The Fall Guy (2) -- 161. The Topic of the Day -- 162. Bounce Back -- 163. Call The Cath Lab! -- 164. The Imatinib Inquiry:Â{u0060}Theoretical Case (For Now) -- 165. A HAART-Breaking Tale -- Part XV. Drug-Drug Interactions Involving Neuropsychiatric Drugs -- 166. Introduction -- 167. Phenytoin (I): Going Crazy! -- 168. Phenytoin (II):The Wrong Drug for the Schizophrenic -- 169. Dizzy and Depressed -- 170. The Funeral Is On Monday -- 171. This Antacid Is Making Me Sick! -- 172. Young at Heart -- 173. Shiver Yes, Die No -- 174. Clip and Dip -- 175. Blue Fog -- 176.

Confiscated Contraceptives -- 177. Gotta Love Derm -- 178. Desperate for A Drink -- Part XVI. Drug-Drug Interactions Involving QT Prolonging DDIs -- 179. Introduction -- 180. Delusion At Heart -- 181. At Long Last -- 182. Metha-donâ€{u4860}-- 183. Flash Fire -- 184. I Am Dizzy When I Stand Up -- Part XVII. Drug-Drug Interactions Involving Foods and Nutrition -- 185. Introduction -- 186. High Fat Diet (I): No Juice For The Ketotic Kid -- 187. Protein Huffing and Puffing -- 188. Salty Sam -- 189. A Peak Potassium Problem -- 190. Awake? -- 191. Tropical Punch Packing a Real Knockout -- 192. When The Fire Wonâ€{u4807}o Out -- 193. Peppermint Patty -- 194. From Bleeding Gums to Green Thumbs- A True Story -- 195. Delicious but Malicious -- 196. I Just Canâ€{u480C}ick This Problem -- 197. Sommelierâ€{u3813}urprise -- 198. Dairy Carefully -- 199. Cold And Sick, Sick And Cold -- 200. TPN (I):Â{u0060}Review and Two Interactions -- 201. TPN (II):Â{u0060}Traumatic Case of Increased Metabolism -- 202. Skin and Bones -- 203. Enough to Make You Sick -- 204. Determined and Desperate to Diet -- Part XVIII. Drug-Drug Interactions Involving Spices and Supplements -- 205. Introduction -- 206. Caffeine Crash -- 207....

The occurrence of deleterious or even fatalÂ{u4CB5}g-drug interactions (DDIs)Â{u9BA0}the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook.The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable toÂ{u1BA5}sthesiologists and surgeons, and PharmDs, as well as trainees in those specialties; intensive care staff, including physicians, physician assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics.Â{uE02E}