Modeling Fragile X Syndrome in Human Pluripotent Cells -- Induced Pluripotent Stem Cells in Familial Dilated Cardiomyopathy.-Â{u9BA4}duced Pluripotent Stem Cells and Amyotrophic Lateral Sclerosis -- IPS Cells and Spinocerebellar Ataxia -- Induced Pluripotent Stem Cells and Vascular Disease -- iPS Cells and Cardiomyopathies -- Cancer Stem Cells and Chemoresistance -- Stem Cells in Autism Spectrum Disorders.

Using stem cells to investigate currently untreatable human genetic diseases is the focus of this book. Several applications of the Nobel-Prize winning, revolutionary iPS cell technology are explored in detail, including in schizophrenia, autism, Huntingtonâ€{u3824}isease, Alzheimerâ€{u3824}isease, spinocerebellar ataxia, medulloblastoma heterogeneity, progeria, age-related macular degeneration, and muscular dystrophy . The book is divided into seven sections, each composed of authoritative and detailed chapters. The first section provides a theoretical and practical overview of stem cells in disease modeling. The following sections divide stem cell applications into various classes of pathology- Â{u0CF9}chiatric disorders, neurodegenerative disease, neurogenesis-associated disorders, and laminopathies. Following these sections, the book discusses the future perspectives- and challenges- of iPS technology.Â{u2820} Broad in scope and in audience, Stem Cells in Modeling Human Genetic Diseases Â{u6BF2} postgraduate students, scientists, and clinicians interested in applications of the rapidly developing field of stem cell research in disease modeling and drug development and its dynamic role within regenerative medicine.