Systems approaches to dissecting immunity / Alan Diercks, Alan Aderem -- Studying Salmonellae and Yersiniae host-pathogen interactions using integrated 'omic and modeling / Charles Ansong [and others] -- ChIP-Seq and the complexity of bacterial transcriptional regulation / James Galagan, Anna Lyubetskaya, Antonio Gomes -- The role and contributions of systems biology to the non-human primate model of influenza pathogenesis and vaccinology / Carole Baskin -- 'Omics investigations of HIV and SIV pathogenesis and innate immunity / Robert E. Palermo, Deborah H. Fuller -- Systems biology of vaccination in the elderly / Sai S. Duraisingham [and others] -- Systems biology analyses to define host responses to HCV infection and therapy / Renee C. Ireton, Michael Gale -- Systems biology approach for new target and biomarker identification / I-Ming Wang [and others] -- Insights into proteomic immune cell signaling and communication via data-driven modeling / Kelly F. Benedict, Douglas A.

First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies-oligonucleotide microarrays, mass spectrometry, and next-generation sequencing-and the analysis of this data through sophisticated mathematical algorithms.