1. Introduction and history -- 2. Basic principles of drug delivery and dosing -- 3. Sulfonamides -- 4. Penicillins -- 5. Cephalosporins -- 6. Monobactams: Aztreonam -- 7. Carbapenems -- 8. Glycopeptides and other agents used to treat gram-positive cocci -- 9. Vancomycin: New Area-under-the-curve-based therapeutic monitoring -- 10. Aminoglycosides -- 11. Macrolides -- 12. Metronidazole and clindamycin -- 13. Quinolones -- 14. Tetracyclines -- 15. Pleuromutilin -- 16. Antimicrobial stewardship: evolution into the 21st century -- 17. Clinical approach to the treatment of infectious diseases -- 18. Understanding drug allergies and drug toxicities -- 19. Antibiotic-associated diarrhea -- 20. Principles of antibiotic resistance -- 21. Clinical approach to treatment of bacterial infections -- 22. Clinical approach to treatment of mycobacterial infections -- 23. Clinical approach to treatment of fungal infections -- 24. Clinical approach to treatment of viral infections -- 25. Sample cases and analyses of the use of anti-infective agents: Cases 1-15 -- Appx A. Common infectious diseases and empiric antibiotic recommendations for adult ed and inpatients at UMass Memorial Medical Center -- Appx B. Bioavailability of anti-infective agents -- Appx C. Dosage and intervals for administration of IV antimicrobials -- Appx D. Dosage and intervals for administration of oral antimicrobials -- Appx E. Important interactions with commonly-used anti-infectives -- Appx F. Oral agents that may have interactions with food -- Appx G. Drug interactions with anti-retroviral agents -- Appx H. Dosage in obesity -- Appx I. Recommendations for management of Asymptomatic Bacteriuria (ASB): 2019 update -- Appx J. Guidelines for treatment of C. difficile -- Appx K. Antimicrobial prophylaxis for adult patients with cancer-related immunosuppression -- Appx L. Guidelines for treatment of adults with community-acquired pneumonia -- Appx M. Guidelines for management of adults with hospital-acquired and ventilator-associated pneumonia -- Appx N. Guidelines for antimicrobial prophylaxis for surgery -- Appx O. Guidelines for treatment and chemoprophylaxis of influenza -- Appx P. Antimicrobial dosing in adult patients on extracorporeal membrane oxygenation (EXMO) -- Appx Q. Antimicrobial dosing in neonates.

This second edition of Clinical Use of Anti-Infective Agents provides a comprehensive overview of current approaches to using drugs to treat infections, including historical perspectives, definitions, and discussion of pharmacokinetics and pharmacodynamics and their uses. It includes a detailed explanation of different classes of drugs, outlining their spectrum, pharmacokinetics, side effects, and dosing in clinical settings. This book has been designed as a reference tool for pharmacists, clinicians, nurse practitioners, and clinical microbiologists, as well as a teaching vehicle for students studying infection and patient treatment. Each section includes references allowing for in-depth study of specific agents, Q&As, and illustrative case studies accompanied by commentary on how to approach patients and organisms, optimal methods of making a diagnosis, and prescribing treatment.