"" The GRADE Methodology""

""Preface""; ""Memories from Medical School""; ""Acknowledgments""; ""Contents""; ""Contributors""; ""Chapter 1: History of Infectious Diseases and Vaccines in Society: Introduction""; ""Introduction""; "" Infectious Disease: Its Effects on Culture and Populations""; "" Significant Plagues, Pandemics, and Epidemics""; "" The Path to Vaccine Discovery""; "" Smallpox: From Early Recorded Man to the Twenty-First Century""; "" Variolation and Inoculation: Earliest Forms of Vaccination""; "" Edward Jenner""

"" Closer to Home: Smallpox in Eighteenth-Century Americas and the American Revolution"""" Smallpox Today""; "" Development of the Germ Theory and Early Modern Vaccines""; "" History of Modern Vaccines Late Nineteenth and Twentieth Centuries""; "" Types of Vaccines""; "" Toxoids""; "" Live, Attenuated Vaccines""; "" Inactivated Vaccines""; "" Subunit/Conjugate Vaccines""; "" DNA Vaccines""; "" Diseases and Their Vaccines""; "" Tuberculosis""; "" MMR-Autism Hoax""; "" Creation of the World Health Organization Global Recommendations for Vaccines""; "" Beginnings of CDC""

"" Exploratory Stage"""" Preclinical Stage""; "" Case in Point: Zika virus""; "" Clinical Development Stage""; "" Overview of the Federal Drug Administration""; "" Clinical Trial Process""; "" Case in Point: Meningococcal B Vaccine [17, 18]""; "" Phases of Clinical Testing""; "" FDA Regulatory Review: Biologics License Application ""; "" Vaccines and Related Biological Products Advisory Committee""; "" Vaccine Labeling""; "" Preapproval Review [23]""; "" Post-Approval Surveillance""; "" Case in Point: 9-Valent Human Papillomavirus Vaccine [24, 25]""; "" Vaccine Production""

"" Manufacturing"""" The Centers for Disease Control and Prevention Advisory Committee on Immunization Practice""; "" Authority and Oversight of the ACIP""; "" Scope of ACIP Recommendations and Guidance""; "" Vaccine-Specific Recommendations""; "" Case in Point: Live Attenuated Influenza Vaccine""; "" A New Way to Deliver Vaccine""; "" An Unexpected Lack of Effectiveness""; "" General Recommendations""; "" ACIP Influence on Vaccine Payment""; "" The Affordable Care Act and Immunizations""; "" Vaccines for Children""; "" ACIP Membership""; "" ACIP Meetings""; "" ACIP Workgroups""

"" Vaccine Recommendations in the United States"""" Development of the Vaccines for Children Program""; "" Summary""; ""References""; ""Chapter 2: Vaccine Science and Immunology""; "" Immunology Review""; "" Types of Vaccines""; "" Immunizing Special Populations""; "" Immunization Scheduling""; "" Adjuvants and Additives""; "" Herd Immunity""; "" Summary""; ""References""; ""Chapter 3: Immunization Recommendations and Guidelines: From Development to CDC Recommendations""; "" Overview""; "" Research and Development""; "" Prioritization for Research and Development""

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