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Ultraviolet light in human health, diseases and environment / Shamim I. Ahmad, editor.

Contributor(s): Ahmad, Shamim I., editor literario
Material type: materialTypeLabelE-bookSeries: (Advances in Experimental Medicine and Biology ; v. 996).Publisher: Cham, Switzerland : Springer International Publishing, 2017Description: 1 recurso en línea (367 páginas).ISBN: 3319560174; 9783319560175.Subject: Radiación ultravioletaOnline resources: Acceso a este recurso digital (usuarios Universidad Europea de Madrid)Digital Resources
Contents:
""Dedication""; ""Preface""; ""Acknowledgment""; ""Contents""; ""About the Editor""; ""A Tribute to Aziz Sancar: The Nobel Prize Winner in Chemistry, 2015""; ""Part I: Introduction, Historical Aspects and Sources of UV Light""; ""1: History of UV Lamps, Types, and Their Applications""; ""1.1 Introduction""; ""1.2 The Discovery of UV Light""; ""1.3 The Types of UV Light""; ""1.4 Man-Made UV Generating Lamps""; ""1.4.1 Arc Lamp""; ""1.4.2 Cold-Light UV-A1""; ""1.4.3 Excimer""; ""1.4.4 Fluorescent Lamp""; ""1.4.5 Full Spectrum Light""; ""1.4.6 UV Gas Discharge Lamps""
""1.4.7 Narrowband UVB""""1.4.8 Narrow Band Ultraviolet B and C Lamp""; ""1.4.9 Near UV or UVA Light""; ""1.4.10 Plasma and Synchrotron Sources of Extreme UV""; ""1.4.11 Microwave Discharge Electrodeless Lamp""; ""1.4.12 TL-01 Ultraviolet Lamp""; ""1.4.13 TL-12 Philips Lamp""; ""1.4.14 Black-Light ILTs""; ""1.4.15 UV Light-Emitting Diodes""; ""1.4.16 Ultraviolet Lasers""; ""1.4.17 UVA-1, UVA-2 and a Combination of Both""; ""1.4.18 Short Wave Ultraviolet Lamp""; ""1.5 Phototherapies""; ""1.5.1 UVA1 Phototherapy""; ""1.5.2 PUVA Therapy""; ""1.5.3 Photodynamic Therapy""
""1.5.4 Extracorporeal Photopheresis""""1.6 Conclusion""; ""References""; ""Part II: UV Photoproducts, Damage to DNA and Mutagenesis""; ""2: Ultraviolet Light Induced Generation of Reactive Oxygen Species""; ""2.1 Introduction""; ""2.2 Ultraviolet Light""; ""2.2.1 The Global Solar UV Index (UVI)""; ""2.3 Sources of UV Light""; ""2.3.1 Outdoor""; ""2.3.2 Artificial Sources""; ""2.4 Tissue Exposure to UV""; ""2.5 UV Light Induced Reactive Oxygen Species""; ""2.5.1 What Are Reactive Oxygen Species?""; ""2.5.2 UV â#x80;#x93; Light Induced ROS""; ""2.5.2.1 Catalase""
""2.5.2.2 Nitric Oxide Synthase""""2.5.2.3 Signalling Pathways""; ""2.5.2.4 Protein Kinase C""; ""2.5.2.5 DNA Damage""; ""2.5.3 Biochemical Actions of UV in the Skin""; ""2.6 UV, ROS and Pathophysiological Skin Effects""; ""2.7 Conclusion""; ""References""; ""Part III: UV Light and Human Diseases""; ""3: UV-Induced Molecular Signaling Differences in Melanoma and Non-­melanoma Skin Cancer""; ""3.1 UVR Impact on NMSC""; ""3.1.1 Introduction""; ""3.1.2 UVB-Caused DNA Damage in Keratinocytes and Basal Cells""; ""3.1.3 The DNA Repair Mechanisms""; ""3.1.3.1 The NER System""
""3.1.3.2 The BER System""""3.1.4 UVR and Mutations""; ""3.1.4.1 The p53 Gene""; ""3.1.4.2 PTCH (PATCHED1)""; ""3.1.4.3 PTEN""; ""3.1.4.4 RAS Oncogenes""; ""3.1.4.5 Cell Cycle Genes and HPV Virus Infection""; ""3.1.5 UVR-Induced Immunosuppression""; ""3.1.5.1 The Fas/FasL System""; ""3.1.5.2 Langerhans Cells""; ""3.1.5.3 Natural Killer Cells and Master Cells""; ""3.1.5.4 Cyclooxygenase (COX-2)""; ""3.2 The UV Impact on Melanoma""; ""3.2.1 The UVR-Induced DNA Damage in Melanoma""; ""3.2.1.1 The MAP Kinase Pathway: NRAS and BRAF Oncogenes""
Abstract: This book is about the roles and importance of Ultraviolet (UV) light from sun and from man-made UV lamps in our daily life, on health and diseases, also its application in sterilization and treatment. The key words are: reactive oxygen species, DNA damage, UV mutagenicity, skin cancers, polymorphous light eruption, Xeroderma pigmentosum, vitiligo, psoriasis, rheumatoid arthritis, diabetes mellitus, metabolic syndromes, cardiovascular diseases, dermatology, photobiology, photodermatosis, vitamin D synthesis, vitamin D efficiency, water sterilization, blood sterilization, phototherapies, skin tanning and UV dosimeter. The book starts with introduction to UV light and the history of development of UV lamps and its applications. It then moves to describing the interaction of this light with biological components and the production of reactive oxygen species, their roles in cell signaling, cellular defense from foreign invaders, in mutagenesis leading to skin diseases including vitiligo, polymorphous light eruption and various forms of skin cancer. Then it presents the synthesis and importance of UV light and diseases, induced due to the deficiency of vitamin D. Roles of UV light in sterilization, disinfection, phototherapies are depicted in the next part and finally use and abuse of UV light in tanning salon and the availability and importance of use of UV dosimeter are highlighted. The three main focuses of this book are: - Damage to biological systems by UV light leading to certain skin diseases; most importantly skin cancers. - Importance of UV light in the in vivo synthesis of vitamin D when human bodies are exposed to it. - Diseases caused due to the deficiency of vitamin D and the use of UV lamps in phototherapy and sterilization processes. The editor has considerable experience in publishing medical books and has used it critically selecting the matters which will attract the readers from many areas of medical and non-medical fields. It is hoped that the materials presented in this book will give great benefit and will stimulate both novice and expert researchers in the field. The book gives excellent overviews of the current status of research and pointers to the future research achievements. Clinicians, medical general practitioners, technicians and staff working in UV related industries and especially those working in tanning salon should benefit from the information presented in safe handling of this light. .
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Item type Current library Collection Call number Status Date due Barcode Item holds
LIBRO-E NO PRÉSTAMO LIBRO-E NO PRÉSTAMO Madrid Digital Acceso Electrónico (UEM) FCBS | FCAD QP82.2.U4 .A46 2017 EB (Browse shelf(Opens below)) Acceso electrónico eBook.20024299
Total holds: 0

""3.2.1.2 The Newly Discovered Oncogenes: RAC1and PREX2""

Includes index.

""Dedication""; ""Preface""; ""Acknowledgment""; ""Contents""; ""About the Editor""; ""A Tribute to Aziz Sancar: The Nobel Prize Winner in Chemistry, 2015""; ""Part I: Introduction, Historical Aspects and Sources of UV Light""; ""1: History of UV Lamps, Types, and Their Applications""; ""1.1 Introduction""; ""1.2 The Discovery of UV Light""; ""1.3 The Types of UV Light""; ""1.4 Man-Made UV Generating Lamps""; ""1.4.1 Arc Lamp""; ""1.4.2 Cold-Light UV-A1""; ""1.4.3 Excimer""; ""1.4.4 Fluorescent Lamp""; ""1.4.5 Full Spectrum Light""; ""1.4.6 UV Gas Discharge Lamps""

""1.4.7 Narrowband UVB""""1.4.8 Narrow Band Ultraviolet B and C Lamp""; ""1.4.9 Near UV or UVA Light""; ""1.4.10 Plasma and Synchrotron Sources of Extreme UV""; ""1.4.11 Microwave Discharge Electrodeless Lamp""; ""1.4.12 TL-01 Ultraviolet Lamp""; ""1.4.13 TL-12 Philips Lamp""; ""1.4.14 Black-Light ILTs""; ""1.4.15 UV Light-Emitting Diodes""; ""1.4.16 Ultraviolet Lasers""; ""1.4.17 UVA-1, UVA-2 and a Combination of Both""; ""1.4.18 Short Wave Ultraviolet Lamp""; ""1.5 Phototherapies""; ""1.5.1 UVA1 Phototherapy""; ""1.5.2 PUVA Therapy""; ""1.5.3 Photodynamic Therapy""

""1.5.4 Extracorporeal Photopheresis""""1.6 Conclusion""; ""References""; ""Part II: UV Photoproducts, Damage to DNA and Mutagenesis""; ""2: Ultraviolet Light Induced Generation of Reactive Oxygen Species""; ""2.1 Introduction""; ""2.2 Ultraviolet Light""; ""2.2.1 The Global Solar UV Index (UVI)""; ""2.3 Sources of UV Light""; ""2.3.1 Outdoor""; ""2.3.2 Artificial Sources""; ""2.4 Tissue Exposure to UV""; ""2.5 UV Light Induced Reactive Oxygen Species""; ""2.5.1 What Are Reactive Oxygen Species?""; ""2.5.2 UV â#x80;#x93; Light Induced ROS""; ""2.5.2.1 Catalase""

""2.5.2.2 Nitric Oxide Synthase""""2.5.2.3 Signalling Pathways""; ""2.5.2.4 Protein Kinase C""; ""2.5.2.5 DNA Damage""; ""2.5.3 Biochemical Actions of UV in the Skin""; ""2.6 UV, ROS and Pathophysiological Skin Effects""; ""2.7 Conclusion""; ""References""; ""Part III: UV Light and Human Diseases""; ""3: UV-Induced Molecular Signaling Differences in Melanoma and Non-­melanoma Skin Cancer""; ""3.1 UVR Impact on NMSC""; ""3.1.1 Introduction""; ""3.1.2 UVB-Caused DNA Damage in Keratinocytes and Basal Cells""; ""3.1.3 The DNA Repair Mechanisms""; ""3.1.3.1 The NER System""

""3.1.3.2 The BER System""""3.1.4 UVR and Mutations""; ""3.1.4.1 The p53 Gene""; ""3.1.4.2 PTCH (PATCHED1)""; ""3.1.4.3 PTEN""; ""3.1.4.4 RAS Oncogenes""; ""3.1.4.5 Cell Cycle Genes and HPV Virus Infection""; ""3.1.5 UVR-Induced Immunosuppression""; ""3.1.5.1 The Fas/FasL System""; ""3.1.5.2 Langerhans Cells""; ""3.1.5.3 Natural Killer Cells and Master Cells""; ""3.1.5.4 Cyclooxygenase (COX-2)""; ""3.2 The UV Impact on Melanoma""; ""3.2.1 The UVR-Induced DNA Damage in Melanoma""; ""3.2.1.1 The MAP Kinase Pathway: NRAS and BRAF Oncogenes""

This book is about the roles and importance of Ultraviolet (UV) light from sun and from man-made UV lamps in our daily life, on health and diseases, also its application in sterilization and treatment. The key words are: reactive oxygen species, DNA damage, UV mutagenicity, skin cancers, polymorphous light eruption, Xeroderma pigmentosum, vitiligo, psoriasis, rheumatoid arthritis, diabetes mellitus, metabolic syndromes, cardiovascular diseases, dermatology, photobiology, photodermatosis, vitamin D synthesis, vitamin D efficiency, water sterilization, blood sterilization, phototherapies, skin tanning and UV dosimeter. The book starts with introduction to UV light and the history of development of UV lamps and its applications. It then moves to describing the interaction of this light with biological components and the production of reactive oxygen species, their roles in cell signaling, cellular defense from foreign invaders, in mutagenesis leading to skin diseases including vitiligo, polymorphous light eruption and various forms of skin cancer. Then it presents the synthesis and importance of UV light and diseases, induced due to the deficiency of vitamin D. Roles of UV light in sterilization, disinfection, phototherapies are depicted in the next part and finally use and abuse of UV light in tanning salon and the availability and importance of use of UV dosimeter are highlighted. The three main focuses of this book are: - Damage to biological systems by UV light leading to certain skin diseases; most importantly skin cancers. - Importance of UV light in the in vivo synthesis of vitamin D when human bodies are exposed to it. - Diseases caused due to the deficiency of vitamin D and the use of UV lamps in phototherapy and sterilization processes. The editor has considerable experience in publishing medical books and has used it critically selecting the matters which will attract the readers from many areas of medical and non-medical fields. It is hoped that the materials presented in this book will give great benefit and will stimulate both novice and expert researchers in the field. The book gives excellent overviews of the current status of research and pointers to the future research achievements. Clinicians, medical general practitioners, technicians and staff working in UV related industries and especially those working in tanning salon should benefit from the information presented in safe handling of this light. .

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