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Peptides and peptide-based biomaterials and their biomedical applications / Anwar Sunna, Andrew Care, Peter L. Bergquist, editors.

Contributor(s): Bergquist, Peter L.,, editor literario | Care, Andrew,, editor literario | Sunna, Anwar,, editor literario
Material type: materialTypeLabelE-bookSeries: (Advances in experimental medicine and biology, 0065-2598 ; volume 1030).Publisher: Cham, Switzerland : Springer International Publishing, 2017Description: 1 recurso en línea (xiii, 300 páginas) : ilustraciones (algunas a color).ISBN: 3319660942; 3319660950; 9783319660943; 9783319660950.Subject: Péptidos -- BiotechnologyOnline resources: Acceso a este recurso digital (usuarios Universidad Europea de Madrid)Digital Resources
Contents:
""Preface""; ""Contents""; ""About the Editors""; ""1: Programmable Bio-surfaces for Biomedical Applications""; ""1.1 Introduction""; ""1.2 Sources of Peptide""; ""1.2.1 Natural Peptide""; ""1.2.2 Peptide Derived from Natural Protein""; ""1.2.3 Artificial Peptide""; ""1.3 Functions of Peptides""; ""1.4 Immobilization Methods""; ""1.4.1 Physical Adsorption""; ""1.4.2 SAM-Based Immobilization""; ""1.4.3 Polymer-Based Immobilization""; ""1.4.4 Aptamer-Based Immobilization""; ""1.5 Utilization of Programmable Bio-surfaces""; ""1.6 Conclusions""; ""References""
""2: Solid-Binding Peptides in Biomedicine""""2.1 Introduction""; ""2.1.1 SBP Binding and Synthesis Mechanisms""; ""2.1.2 Isolation of SBPs""; ""2.2 Applications in Biomedicine""; ""2.2.1 Vaccine Development""; ""2.2.2 Bioimaging""; ""2.2.3 Drug Delivery""; ""2.2.4 LPG â#x80;#x93; Cell Capture""; ""2.2.5 Biocompatibility""; ""2.2.6 Biomedical Diagnostics""; ""2.2.7 Anti-microbial Therapeutics""; ""2.2.8 Surgical Implants and Biomaterials for Biomedicine""; ""2.3 Concluding Remarks and Future Perspectives""; ""References""
""3: Molecular Modelling of Peptide-Based Materials for Biomedical Applications""""3.1 Introduction""; ""3.2 Hydroxyapatite-Based Materials""; ""3.2.1 Progress in Molecular Simulations of the Peptide-HAp Interface""; ""3.2.2 Outlook for Molecular Simulations of the Peptide-HAp Interface""; ""3.3 Titania-Based Materials""; ""3.3.1 Progress in Molecular Simulations of the Peptide-Titania Interface""; ""3.3.2 Outlook for Molecular Simulations of the Peptide-Titania Interface""; ""3.4 Outlook and Future Prospects""; ""References""
""4.3.2.1 14-Helix""""4.3.2.2 12-Helix""; ""4.3.2.3 10-Helix, 10/12 or 12/10-Helix""; ""4.3.2.4 8-Helix""; ""4.3.2.5 C6-Ribbon""; ""4.3.2.6 β Sheet-Like Structures (Parallel Sheets)""; ""4.3.3 Peptoids""; ""4.3.4 Hybrid α/β Peptides""; ""4.4 Factors Affecting β-Peptide Folding""; ""4.5 Self-Assembled Oligopeptide Superstructures""; ""4.6 Engineering Unnatural Supramolecular Structures""; ""4.6.1 Amphiphiles Based on α-Peptides""; ""4.6.2 Self-Assembly of α-Helical Building Blocks""; ""4.6.3 Amphiphiles Based on β-Peptides""
""4: Design Principles of Peptide Based Self-Assembled Nanomaterials""""4.1 Introduction""; ""4.2 Self-Assembly""; ""4.2.1 Interactions That Drive Self-Assembly""; ""4.2.1.1 Hydrogen Bonding""; ""4.2.1.2 Van der Waals Interactions""; ""4.2.1.3 Solvophobic Interactions""; ""4.2.1.4 Electrostatic Interactions""; ""4.2.1.5 Aromatic Interactions (Ï#x80;-Ï#x80; Stacking)""; ""4.3 Bioinspired Building Blocks of Self-Assembly""; ""4.3.1 Secondary Structures of α-Peptides""; ""4.3.1.1 β-Sheet""; ""4.3.1.2 α-Helix""; ""4.3.1.3 310 Helix""; ""4.3.2 Secondary Structures of β-Peptides""
Abstract: This edited volume is composed of chapters written by experts in the field describing fundamental research on small peptide fragments in relation to their biological action and potential roles in biomedical applications from diagnosis to implant protection. It provides a review of the wide scope and significance of these relatively simple arrays of amino acids that have the ability to bind to surfaces of all kinds and can facilitate the autonomous assembly of structures in nanotechnology as well as penetrating cell membranes and delivering therapeutic drugs. Readers will learn of some of the impediments to a wider and more comprehensive catalog of these molecules and of some of the attributes of rationally-designed and chemically synthesised peptides as anticancer agents. An overview is provided of the expansive variety of biological leads for biomedically relevant peptides as well as the wide array of tissues and biological, bioactive scaffolds that are dependent on these short peptide sequences addressing topics such as cartilage and hard tissue initiation and regeneration and the transition of active reagents from molluscs to drug leads for the treatment of chronic pain. Peptides can possess surface-specific non-covalent adsorption properties that can be exploited to enhance the functionality of medical implant materials but their implementation is largely on a trial-and-error basis because an understanding of general structure/function relationships is lacking. Molecular simulation approaches can provide relevant details at the atomic scale and prospects for advancing peptide-mediated medical implant surface treatments via molecular simulation are summarized. The literature has papers emphasizing the role of peptides in the design of biohybrid functional surfaces and there has been a growing interest in applying peptides as materials-selective assemblers and self-organizers, but applications are based largely on an empirical understanding of solid surface binding characteristics, as reviewed here. The present work is written for researchers who may be considering entering this field and are exposed to a mass of fundamental research information on individual applications. It has been our intention to trace how and where the research has emerged and to outline the opportunities we see to develop novel and well-grounded tools for specific therapeutic scenarios.
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Item type Current library Collection Call number Status Date due Barcode Item holds
LIBRO-E NO PRÉSTAMO LIBRO-E NO PRÉSTAMO Madrid Digital Acceso Electrónico (UEM) FCBS | FCAD QP552.P4 .B47 2017 EB (Browse shelf(Opens below)) Acceso electrónico eBook.20024255
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Includes index.

""Preface""; ""Contents""; ""About the Editors""; ""1: Programmable Bio-surfaces for Biomedical Applications""; ""1.1 Introduction""; ""1.2 Sources of Peptide""; ""1.2.1 Natural Peptide""; ""1.2.2 Peptide Derived from Natural Protein""; ""1.2.3 Artificial Peptide""; ""1.3 Functions of Peptides""; ""1.4 Immobilization Methods""; ""1.4.1 Physical Adsorption""; ""1.4.2 SAM-Based Immobilization""; ""1.4.3 Polymer-Based Immobilization""; ""1.4.4 Aptamer-Based Immobilization""; ""1.5 Utilization of Programmable Bio-surfaces""; ""1.6 Conclusions""; ""References""

""2: Solid-Binding Peptides in Biomedicine""""2.1 Introduction""; ""2.1.1 SBP Binding and Synthesis Mechanisms""; ""2.1.2 Isolation of SBPs""; ""2.2 Applications in Biomedicine""; ""2.2.1 Vaccine Development""; ""2.2.2 Bioimaging""; ""2.2.3 Drug Delivery""; ""2.2.4 LPG â#x80;#x93; Cell Capture""; ""2.2.5 Biocompatibility""; ""2.2.6 Biomedical Diagnostics""; ""2.2.7 Anti-microbial Therapeutics""; ""2.2.8 Surgical Implants and Biomaterials for Biomedicine""; ""2.3 Concluding Remarks and Future Perspectives""; ""References""

""3: Molecular Modelling of Peptide-Based Materials for Biomedical Applications""""3.1 Introduction""; ""3.2 Hydroxyapatite-Based Materials""; ""3.2.1 Progress in Molecular Simulations of the Peptide-HAp Interface""; ""3.2.2 Outlook for Molecular Simulations of the Peptide-HAp Interface""; ""3.3 Titania-Based Materials""; ""3.3.1 Progress in Molecular Simulations of the Peptide-Titania Interface""; ""3.3.2 Outlook for Molecular Simulations of the Peptide-Titania Interface""; ""3.4 Outlook and Future Prospects""; ""References""

""4.3.2.1 14-Helix""""4.3.2.2 12-Helix""; ""4.3.2.3 10-Helix, 10/12 or 12/10-Helix""; ""4.3.2.4 8-Helix""; ""4.3.2.5 C6-Ribbon""; ""4.3.2.6 β Sheet-Like Structures (Parallel Sheets)""; ""4.3.3 Peptoids""; ""4.3.4 Hybrid α/β Peptides""; ""4.4 Factors Affecting β-Peptide Folding""; ""4.5 Self-Assembled Oligopeptide Superstructures""; ""4.6 Engineering Unnatural Supramolecular Structures""; ""4.6.1 Amphiphiles Based on α-Peptides""; ""4.6.2 Self-Assembly of α-Helical Building Blocks""; ""4.6.3 Amphiphiles Based on β-Peptides""

""4: Design Principles of Peptide Based Self-Assembled Nanomaterials""""4.1 Introduction""; ""4.2 Self-Assembly""; ""4.2.1 Interactions That Drive Self-Assembly""; ""4.2.1.1 Hydrogen Bonding""; ""4.2.1.2 Van der Waals Interactions""; ""4.2.1.3 Solvophobic Interactions""; ""4.2.1.4 Electrostatic Interactions""; ""4.2.1.5 Aromatic Interactions (Ï#x80;-Ï#x80; Stacking)""; ""4.3 Bioinspired Building Blocks of Self-Assembly""; ""4.3.1 Secondary Structures of α-Peptides""; ""4.3.1.1 β-Sheet""; ""4.3.1.2 α-Helix""; ""4.3.1.3 310 Helix""; ""4.3.2 Secondary Structures of β-Peptides""

This edited volume is composed of chapters written by experts in the field describing fundamental research on small peptide fragments in relation to their biological action and potential roles in biomedical applications from diagnosis to implant protection. It provides a review of the wide scope and significance of these relatively simple arrays of amino acids that have the ability to bind to surfaces of all kinds and can facilitate the autonomous assembly of structures in nanotechnology as well as penetrating cell membranes and delivering therapeutic drugs. Readers will learn of some of the impediments to a wider and more comprehensive catalog of these molecules and of some of the attributes of rationally-designed and chemically synthesised peptides as anticancer agents. An overview is provided of the expansive variety of biological leads for biomedically relevant peptides as well as the wide array of tissues and biological, bioactive scaffolds that are dependent on these short peptide sequences addressing topics such as cartilage and hard tissue initiation and regeneration and the transition of active reagents from molluscs to drug leads for the treatment of chronic pain. Peptides can possess surface-specific non-covalent adsorption properties that can be exploited to enhance the functionality of medical implant materials but their implementation is largely on a trial-and-error basis because an understanding of general structure/function relationships is lacking. Molecular simulation approaches can provide relevant details at the atomic scale and prospects for advancing peptide-mediated medical implant surface treatments via molecular simulation are summarized. The literature has papers emphasizing the role of peptides in the design of biohybrid functional surfaces and there has been a growing interest in applying peptides as materials-selective assemblers and self-organizers, but applications are based largely on an empirical understanding of solid surface binding characteristics, as reviewed here. The present work is written for researchers who may be considering entering this field and are exposed to a mass of fundamental research information on individual applications. It has been our intention to trace how and where the research has emerged and to outline the opportunities we see to develop novel and well-grounded tools for specific therapeutic scenarios.

Online resource; title from PDF title page (EBSCO, viewed November 1, 2017).

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