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Protein deimination in human health and disease / Anthony P. Nicholas, Sanjoy K. Bhattacharya, Paul R. Thompson, editors.

Contributor(s): Bhattacharya, Sanjoy K., (Professor of ophthalmology), editor literario | Nicholas, Anthony P.,, editor literario | Thompson, Paul R.,, editor literario
Material type: materialTypeLabelE-bookPublisher: Cham, Switzerland : Springer International Publishing, 2017Copyright date: 2017Edition: Second edition.Description: 1 recurso en línea.ISBN: 3319582445; 9783319582443.Subject: Proteínas | InmunologíaOnline resources: Acceso a este recurso digital (usuarios Universidad Europea de Madrid)Digital Resources
Contents:
Dedication; Contents; Chapter 1: A History of Deimination Research in Japan: The Founding Fathers; References; Chapter 2: Aspects of Peptidylarginine Deiminase Regulation that May Predispose to Autoreactivity Against Citrullinated Proteins; 2.1 Summary; 2.2 Tolerance and Autoimmunity; 2.3 Discovery of Arginine Deimination; 2.4 Role of PAD4 in Innate Immune Responses; 2.5 PAD4 and NETs; 2.6 NETs in Autoimmunity; 2.7 Model of PAD4 Activation in the Pathogenesis of Autoimmune Disease; References; Chapter 3: Structures and Functions of Peptidylarginine Deiminases; 3.1 Introduction
3.2 PAD Isozymes: Similarities and Differences3.2.1 Overall Folds; 3.2.2 Structures and the Functions of the Catalytic Domains; 3.2.3 Ca2+-Binding Sites and Functions; 3.2.4 Structures and the Functions of N-Terminal Ig-Like Domain; 3.3 Application of PAD Structures for Drug Design; 3.4 Conclusions; References; Chapter 4: The Use of Genetically Engineered Mice to Study PAD Biology and Pathology; 4.1 Introduction; 4.2 PAD2; 4.3 PAD3; 4.4 PAD4; 4.5 PAD6; 4.6 Conclusions; References; Chapter 5: PAD Activation in Arthritis; 5.1 Introduction; 5.2 Methods to Determine PAD Activity
5.3 PAD Substrate Specificity5.4 PAD Isoforms Involved in Arthritis; 5.4.1 PAD2 and PAD4 Expression in Hematopoietic Cells; 5.4.2 PAD2 and PAD4 Expression in Joints; 5.5 PAD Activation; 5.5.1 Calcium; 5.5.2 Reducing Conditions; 5.6 PAD and NETosis; 5.7 PAD Activation and Citrullination in Relation to Inflammation in RA; 5.8 Citrullinated Proteins in Synovial Fluid; 5.9 Concluding Remarks; References; Chapter 6: Rheumatoid Arthritis: Transition from Systemic Autoimmunity to Joint Inflammation and Bone Loss; 6.1 Introduction
6.2 The Immune System Might Be Primed Against Citrullinated Autoantigens at Mucosal Extra-­Articular Sites6.3 Autoimmunity Against Citrullinated Proteins Gradually Develops and Precedes Chronic Joint Inflammation; 6.4 ACPAs Target Maturing Osteoclasts Leading to Bone Loss and Pain in the Absence of Inflammation; 6.5 Summary; References; Chapter 7: Porphyromonas gingivalis Peptidyl Arginine Deiminase: A Unique Bacterial PAD with Implications for Periodontal Disease and Rheumatoid Arthritis; 7.1 Introduction; 7.2 Epidemiology, Etiology, and Clinical Features of PD
7.3 Oral Cavity Colonization and PD7.4 Porphyromonas gingivalis Is a Main Causative Agent of PD in Adult Population; 7.5 Citrullination Is a Posttranslational Modification Catalyzed by Peptidyl Arginine Deiminases; 7.5.1 Citrullination Catalyzed by PAD/PADI Is a Common Physiological Protein Modification; 7.5.2 Citrullination Catalyzed by PAD/PADI Is Implicated in the Pathogenesis of Several Diseases; 7.5.3 Citrullination Catalyzed by PPAD Is a Unique Feature of P. gingivalis; 7.5.4 Biochemical Properties of PPAD; 7.5.5 The Facts and Hypotheses on PPAD Implication in the Pathogenesis of PD
Abstract: Chronicling the earliest studies of deimination in the nervous system up to the present, this volume distills what is currently known about citrullination of proteins in the eye and nervous system.
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Item type Current library Collection Call number Status Date due Barcode Item holds
LIBRO-E NO PRÉSTAMO LIBRO-E NO PRÉSTAMO Madrid Digital Acceso Electrónico (UEM) FCBS | FCAD QP601.3 P768 2017 EB (Browse shelf(Opens below)) Acceso electrónico eBook.20024160
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7.6 The Associations of PD with Systemic Diseases: A General Concept

Springer Biomedical and Life Sciences eBooks 2017 English+International

Incluye referencias bibliográficas e índice

Dedication; Contents; Chapter 1: A History of Deimination Research in Japan: The Founding Fathers; References; Chapter 2: Aspects of Peptidylarginine Deiminase Regulation that May Predispose to Autoreactivity Against Citrullinated Proteins; 2.1 Summary; 2.2 Tolerance and Autoimmunity; 2.3 Discovery of Arginine Deimination; 2.4 Role of PAD4 in Innate Immune Responses; 2.5 PAD4 and NETs; 2.6 NETs in Autoimmunity; 2.7 Model of PAD4 Activation in the Pathogenesis of Autoimmune Disease; References; Chapter 3: Structures and Functions of Peptidylarginine Deiminases; 3.1 Introduction

3.2 PAD Isozymes: Similarities and Differences3.2.1 Overall Folds; 3.2.2 Structures and the Functions of the Catalytic Domains; 3.2.3 Ca2+-Binding Sites and Functions; 3.2.4 Structures and the Functions of N-Terminal Ig-Like Domain; 3.3 Application of PAD Structures for Drug Design; 3.4 Conclusions; References; Chapter 4: The Use of Genetically Engineered Mice to Study PAD Biology and Pathology; 4.1 Introduction; 4.2 PAD2; 4.3 PAD3; 4.4 PAD4; 4.5 PAD6; 4.6 Conclusions; References; Chapter 5: PAD Activation in Arthritis; 5.1 Introduction; 5.2 Methods to Determine PAD Activity

5.3 PAD Substrate Specificity5.4 PAD Isoforms Involved in Arthritis; 5.4.1 PAD2 and PAD4 Expression in Hematopoietic Cells; 5.4.2 PAD2 and PAD4 Expression in Joints; 5.5 PAD Activation; 5.5.1 Calcium; 5.5.2 Reducing Conditions; 5.6 PAD and NETosis; 5.7 PAD Activation and Citrullination in Relation to Inflammation in RA; 5.8 Citrullinated Proteins in Synovial Fluid; 5.9 Concluding Remarks; References; Chapter 6: Rheumatoid Arthritis: Transition from Systemic Autoimmunity to Joint Inflammation and Bone Loss; 6.1 Introduction

6.2 The Immune System Might Be Primed Against Citrullinated Autoantigens at Mucosal Extra-­Articular Sites6.3 Autoimmunity Against Citrullinated Proteins Gradually Develops and Precedes Chronic Joint Inflammation; 6.4 ACPAs Target Maturing Osteoclasts Leading to Bone Loss and Pain in the Absence of Inflammation; 6.5 Summary; References; Chapter 7: Porphyromonas gingivalis Peptidyl Arginine Deiminase: A Unique Bacterial PAD with Implications for Periodontal Disease and Rheumatoid Arthritis; 7.1 Introduction; 7.2 Epidemiology, Etiology, and Clinical Features of PD

7.3 Oral Cavity Colonization and PD7.4 Porphyromonas gingivalis Is a Main Causative Agent of PD in Adult Population; 7.5 Citrullination Is a Posttranslational Modification Catalyzed by Peptidyl Arginine Deiminases; 7.5.1 Citrullination Catalyzed by PAD/PADI Is a Common Physiological Protein Modification; 7.5.2 Citrullination Catalyzed by PAD/PADI Is Implicated in the Pathogenesis of Several Diseases; 7.5.3 Citrullination Catalyzed by PPAD Is a Unique Feature of P. gingivalis; 7.5.4 Biochemical Properties of PPAD; 7.5.5 The Facts and Hypotheses on PPAD Implication in the Pathogenesis of PD

Chronicling the earliest studies of deimination in the nervous system up to the present, this volume distills what is currently known about citrullination of proteins in the eye and nervous system.

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