Incluye referencias bibliográficas e índice

Biomarkers and Endometriosis: The Needto Move Beyond Innovation to Validation; Contents; Contributors; Building Translational Research Infrastructure and Access to Expertise for Biomarker Discovery in Cancer; Introduction; Personalised Medicine and the Use of Biomarkers; The Need for Translational Research Infrastructure; Key Elements of Translational Research Infrastructure and Accessing Expertise; Clinical Use; Management of the Biosample Life Cycle; Quality of Biosamples and the Associated Data; Selection of Collected Biosamples; Accessibility of Biosamples

Future Use of Biosamples Clinical Phenotyping; Biomarker Analysis; A Variety of High-Throughput Platforms for Molecular Analysis; Assay Robustness, Reproducibility and Analytical Validation; Clinical Validity and Clinical Utility; Data Management; Clinical Data; Biosample Metadata; Molecular Data; Interoperable Databases and Information Technology; Data Analysis; Biostatistics; Bioinformatics and System Biology; Verifying Quality and Expertise, Quality Assurance and Quality Control; Quality Assurance of Laboratory Testing; Quality Assurance in Biobanking

Hysteroscopy and Endometrial BiopsyStaging; Treatment; Molecular Biology and Genetics of EC; Type 1 (Endometrioid) EC; Type 2 (Serous and Clear Cell) EC; Diagnostic/Screening Markers; Prognostic/Staging Biomarkers; Tissue Biomarkers; Serum Biomarkers; Conclusions and Future Approaches; References; Biomarker Development in Chronic Inflammatory Diseases; Introduction; Biomarkers in Inflammatory Bowel Diseases; Serological Biomarkers of Acute Phase Response; C-reactive Protein; Erythrocyte Sedimentation Rate; Platelets; Serological Markers with Restricted Clinical Use in IBD

Logistics and Operational Support Governance; Ethical Principles for the Use of Biosamples in Research; Use and Reuse of Data in Biomarker Research; Future Trends: New Ways of Working; Industry-Academia Partnerships; Open Innovation Applied to Biomarker Signature Discovery; Collaborative Platforms for Harmonisation and Exchange; Recognising the Benefits of Sharing; Conclusions; References; Biomarkers of Endometrial Cancer; Introduction; Epidemiology; Aetiology and Risk Factors; The Dualistic Model; Clinical Presentation; Investigations; Transvaginal Ultrasound

Orosomucoid Anti-Saccharomyces cerevisiae Antibodies; Anti-neutrophil Cytoplasmic Antibodies; Anti-glycan Antibodies; Antibody to Outer Membrane Porin (Anti-OmpC); Anti-flagellin Antibodies; Anti-Cbir1; Antibody to Pseudomonas fluorescens: Associated Sequence I2 (Anti-I2); Antibodies to Flagellins A4-Fla2 and Fla-X; Emerging Serological Markers in IBD: Cytokines; Interleukins; TNF-a and TNFa Receptors; Fecal Biomarkers in IBD; Fecal Calprotectin; Fecal Lactoferrin; Biomarkers in Chronic Inflammatory Diseases of Hepatology

"This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide."-- Provided by publisher.

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