880-01 Preface; Contents; Part I: Adipose Tissue Biology and Crosstalks; Chapter 1: Function and Dysfunction of Adipose Tissue; 1.1 Adipose Tissue Structure; 1.2 Metabolic Functions of the Adipose Tissue; 1.2.1 Mechanisms of Nutrient Uptake and Storage in Adipocytes; 1.2.2 Cholesterol Fluxes; 1.3 Endocrine Function of the Adipose Tissue; 1.3.1 Leptin; 1.3.2 Adiponectin; 1.3.3 Resistin; 1.3.4 Other Adipose Tissue Products; 1.4 Dysregulation of Adipose Tissue Function in Obesity; 1.4.1 Dysregulation of Lipid Metabolism; 1.4.2 Adipose Tissue Hypoxia

2.2 Brain Circuits of Food Intake Regulation2.2.1 Hypothalamus; 2.2.1.1 Arcuate Nucleus; 2.2.1.2 Paraventricular Nucleus; 2.2.1.3 Ventromedial Hypothalamus and Dorsomedial Hypothalamus; 2.2.1.4 Lateral Hypothalamic Area; 2.2.1.5 Glucose and Lipid Sense Neurons; 2.2.2 Brainstem; 2.2.3 Brain Reward Circuits; 2.3 Neuronal and Humoral Outputs to the Peripheral Organs; 2.3.1 Central Nervous System and White Adipose Tissue; 2.3.2 Central Nervous System and Brown Adipose Tissue; 2.4 Concluding Remarks; References; Chapter 3: Neuroendocrinology of Adipose Tissue and Gut-Brain Axis; 3.1 Introduction

3.2 Gastrointestinal Signals to the Brain3.2.1 Orexigenic Factors; 3.2.1.1 Ghrelin; 3.2.1.2 Endocannabinoids; 3.2.2 Anorexigenic Factors; 3.2.2.1 Cholecystokinin; 3.2.2.2 Glucagon-like-Peptide-1; 3.2.2.3 Glucagon-like Peptide-2; 3.2.2.4 Peptide Tyrosine Tyrosine; 3.2.2.5 Oxyntomodulin; 3.2.2.6 Gastric Leptin; 3.2.2.7 Apolipoprotein-IV; 3.2.2.8 Neurotensin; 3.2.2.9 Secretin; 3.2.2.10 GUT Microbiota; 3.3 Endocrine Pancreas-Derived Signals to the Brain; 3.3.1 Insulin; 3.3.2 Glucagon; 3.3.3 Amylin; 3.3.4 Pancreatic Polypeptide; 3.4 Adipose Tissue-Derived Signals to the Brain; 3.4.1 Leptin

3.4.2 Adiponectin3.4.3 Resistin; 3.4.4 Apelin; 3.5 Concluding Remarks; References; Part II: Obesity as a Risk Factor for Neurological Disease; Chapter 4: Hypothalamic Dysfunction in Obesity and Metabolic Disorders; 4.1 Introduction; 4.2 Changes of Hypothalamic Food Intake Regulation Controlled by the Hypothalamus; 4.2.1 Obesity Induces Insulin, Leptin, and Ghrelin Resistance in the Hypothalamus; 4.2.1.1 Hypothalamic Insulin Resistance in Obesity; 4.2.1.2 Hypothalamic Leptin Resistance in Obesity; 4.2.1.3 Hypothalamic Ghrelin Resistance in Obesity

This compendium provides a wide view covering everything from molecular mechanisms and risk factors for neurological disorders to the effects of bariatric surgery on brain function and functional neuroimaging applied to obesity research. The impact of obesity on brain function and the development of neurodegenerative and neuroinflammatory disorders has been understudied, despite the recent proliferation of obesity research. Among the topics covered are adipose biology, the adipose tissue - gut - brain axis, brain energy metabolism, dementia, cerebrovascular disease, and multiple sclerosis.

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