Incluye referencias bibliográficas

Preface; Canine Dementia: Unbearable Lightness of Ageing; Acknowledgements; Contents; 1: Clinical Picture of Canine and Feline Cognitive Impairment; 1.1 Clinical Signs of Cognitive Dysfunction; 1.2 Prevalence of Behavior Signs in Senior Pets; 1.3 Pet Owner Reporting; 1.4 Diagnosis; 1.5 Senior Cognition and Decline in Learning and Memory; 1.6 Neuropsychological and Behavioral Assessment; 1.7 Summary; References; 2: Behavioural and Medical Differentials of Cognitive Decline and Dementia in Dogs and Cats; 2.1 Differential Diagnosis of CDS

2.1.1 Behavioural Differentials of CDS in Dogs and Cats2.1.1.1 Anxiety; 2.1.1.2 Fear; 2.1.1.3 Night-Time Waking; 2.1.1.4 Excessive Vocalisation; 2.1.1.5 House Soiling; 2.1.1.6 Aggression; 2.1.1.7 Repetitive Behaviours; 2.1.2 Medical Differentials of CDS in Dogs and Cats; 2.1.2.1 Sensory Decline; 2.1.2.2 Pain; 2.1.2.3 Cardiovascular Disease; 2.1.2.4 Endocrine Disease; 2.1.2.5 Gastrointestinal Disease; 2.1.2.6 Urinary System Disease; 2.1.3 Neurological Differentials of CDS in Dogs and Cats; 2.2 Diagnostic Approach to Reach a Presumptive Diagnosis of CDS; 2.2.1 Signalment

2.2.2 History Taking2.2.2.1 Disorientation; 2.2.2.2 Alterations in Interactions with Owners, Other Pets and the Environment; 2.2.2.3 House Soiling; 2.2.2.4 Changes in Activity; 2.2.2.5 Establishment of the Most Relevant Complaint(s); 2.2.3 Patient Examination; 2.2.3.1 Physical Examination; 2.2.3.2 Orthopaedic Examination; 2.2.3.3 Ophthalmological Examination; 2.2.3.4 Neurological Examination; 2.2.3.5 Changes on Neurological Examination that Would Not Be Expected with CDS; 2.2.4 Problem List and Differential Diagnosis; 2.2.4.1 Problem List; 2.2.4.2 Differential List

2.2.4.12 Toxic Differential: Lead Poisoning2.2.4.13 Vascular; Hypertensive Encephalopathy; Cerebrovascular Accidents; 2.2.5 Diagnostic Testing; 2.2.5.1 Laboratory Testing; 2.2.5.2 Blood Pressure; 2.2.5.3 Advanced Imaging; 2.2.5.4 CSF Analysis; 2.2.5.5 Additional Testing; 2.2.6 Summary; References; 3: Phenotypic Variability and Clinical Staging of Canine Dementia; 3.1 The Clinical Picture of Canine Dementia in a Nutshell; 3.1.1 Disorientation and Activity Changes; 3.1.2 Changes in Social Interactions; 3.1.3 Sleep and Wakefulness Cycle Changes; 3.1.4 Changes in Hygiene Habits

2.2.4.3 Differential Diagnosis: DAMNITV2.2.4.4 Degenerative Differentials; Ceroid Lipofuscinosis; L-2-Hydroxyglutaric Aciduria; Other Neurodegenerative Diseases; 2.2.4.5 Anomalous: Brain Malformations; 2.2.4.6 Metabolic Differentials; Hypoglycaemia; Hepatic Encephalopathy; Renal Encephalopathy; Electrolytes Disturbances; 2.2.4.7 Nutritional; Vitamin B1 Deficiency; Vitamin E Deficiency; 2.2.4.8 Neoplastic Brain Disease; 2.2.4.9 Inflammatory Non-infectious Brain Disease; 2.2.4.10 Infectious Brain Disease; 2.2.4.11 Traumatic Differential: Chronic Repetitive Traumatic Brain Injury

The book deeply focuses on the epidemiology, diagnostics, therapy and molecular basis of canine and feline dementia or cognitive dysfunction syndrome. The aim is to provide a broad overview of the current knowledge on canine and feline dementia. Experiences of clinicians are appropriately linked with current scientific knowledge in a readily comprehensible form. In the first three chapters we describe the clinical pictures of canine and feline dementia, discuss the medical causes of the disease and its phenotypic variability. In the 4th chapter we introduce the dog as an appropriate animal model for human Alzheimer's disease progression. Then we shed light on the neuropathological hallmarks of canine and feline dementia. For the first time we touch upon the modern diagnostic approaches based on the neuroproteomic technological progress. Last but not least, we address the current pharmacological and non-pharmacological approaches for therapy and risk and protective factors of feline and canine dementia. The book addresses clinicians, researchers, university teachers and graduate students in veterinary neurology and medicine.