Incluye referencias bibliográficas e índice

SOCE: fundamental mechanistic concepts. Introduction / James W. Putney -- The STIM-Orai pathway: STIM-Orai structures: isolated and in complex / Jinhui Zhu, Qingping Feng, Peter B. Stathopulos -- The STIM-Orai pathway: Orai, the pore-forming subunit of the CRAC channel / Aparna Gudlur, Patrick G. Hogan -- The STIM-Orai pathway: the interactions between STIM and Orai / Marc Fahrner, Rainer Schindl, Martin Muik, Isabella Derler, Christoph Romanin -- The STIM-Orai pathway: conformational coupling between STIM and Orai in the activation of store-operated Ca2+ entry / Robert M. Nwokonko, Xiangyu Cai, Natalia A. Loktionova, Youjun Wang, Yandong Zhou [and others] -- The STIM-Orai pathway: regulation of STIM and Orai by thiol modifications / Barbara A. Niemeyer -- The STIM-Orai pathway: light-operated Ca2+ entry through engineered CRAC channels / Guolin Ma, Shufan Wen, Yun Huang, Yubin Zhou -- STIM-TRPpathways and microdomain organization: Ca2+ influx channels: the Orai-STIM1-TRPC complexes / Dora Bodnar, Woo Young Chung, Dongki Yang, Jeong Hee Hong, Archana Jha, Shmuel Muallem -- STIM-TRP pathways and microdomain organization: contribution of TRPC1 in store-operated Ca2+ entry: impact on Ca2+ signaling and cell function / Hwei Ling Ong, Indu S. Ambudkar -- STIM-TRP pathways and microdomain organization: auxiliary proteins of the STIM/Orai complex / Jonathan Pacheco, Luis Vaca -- SOCE: crosstalk between organelle and cellular compartments. introduction / Alexei V. Tepikin -- New aspects of the contribution of ER to SOCE regulation: the role of the ER and ER-plasma membrane junctions in the regulation of SOCE / Hayley Dingsdale, Emmanuel Okeke, Lee Haynes, Gyorgy Lur, Alexei V. Tepikin -- New aspects of the contribution of ER to SOCE regulation: TRPC proteins as a link between plasma membrane ion transport and intracellular Ca2+ stores / Alexis Bavencoffe, Michael Xi Zhu, Jin-bin Tian -- The role of mitochondria in the activation/maintenance of SOCE: store-operated Ca2+ entry and mitochondria / András Spät, Gerg̲ Szanda -- The role of mitochondria in the activation/maintenance of SOCE: membrane contact sites as signaling hubs sustaining store-operated Ca2+ entry / Nicolas Demaurex, Daniele Guido -- The role of mitochondria in the activation/maintenance of SOCE: the contribution of mitochondrial Ca2+ uptake, mitochondrial motility, and location to store-operated Ca2+ entry / Roland Malli, Wolfgang F. Graier -- Tissue specificity: the role of organellar membrane nanojunctions in smooth muscle Ca2+ signaling / Nicola Fameli, A. Mark Evans, Cornelis van Breemen -- Tissue specificity: SOCE: implications for Ca2+ handling in endothelial cells / Lothar A. Blatter -- Tissue specificity: store-operated Ca2+ entry in cardiac myocytes / Martin D. Bootman, Katja Rietdorf -- SOCE: molecular and cellular (patho)physiology. Introduction: overview of the pathophysiological implications of store-operated calcium entry in mammalian cells / Juan A. Rosado -- Immunological disorders: regulation of Ca2+ signaling in T lymphocytes / Sonal Srikanth, Jin Seok Woo, Zuoming Sun, Yousang Gwack -- Cardiovascular and hemostatic disorders: role of STIM and Orai proteins in vascular disorders / Jyoti Tanwar, Mohamed Trebak, Rajender K. Motiani -- Cardiovascular and hemostatic disorders: SOCE and Ca2+ handling in platelet dysfunction / Jose J. Lopez, Gines M. Salido, Juan A. Rosado -- Cardiovascular and hemostatic disorders: SOCE in cardiovascular cells: emerging targets for therapeutic intervention / Klaus Groschner, Niroj Shrestha, Nicola Fameli -- Cardiac remodeling and disease: SOCE and TRPC signaling in cardiac pathology / Petra Eder -- Cardiac remodeling and disease: current understanding of STIM1/Orai1-mediated store-operated Ca2+ entry in cardiac function and pathology / Fiona Bartoli, Jessica Sabourin -- Neurological and motor disorders: neuronal store-operated Ca2+ signaling: an overview and its function / Sunitha Bollimuntha, Biswaranjan Pani, Brij B. Singh -- Neurological and motor disorders: TRPC in the skeletal muscle / Sophie Saüc, Maud Frieden -- Fertility: store-operated Ca2+ entry in germ cells: role in egg activation / Zoltan Machaty, Chunmin Wang, Kiho Lee, Lu Zhang -- Metabolic disorders and cancer: hepatocyte store-operated Ca2+ channels in nonalcoholic fatty liver disease / Eunüs S. Ali, Grigori Y. Rychkov, Greg J. Barritt -- Metabolic disorders and cancer: store-operated Ca2+ entry in cancer: focus on IP3R-mediated Ca2+ release from intracellular stores and its role in migration and invasion / Abigael Ritaine, George Shapovalov, Natalia Prevarskaya.

"This second edition of the book on Store-operated Ca2+ Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years. The crystal structure of the Ca2+ signaling core complex is described which adds to a new understanding of the molecular interactions involved. Each chapter has been revised and extended. The book retains its interdisciplinary approach and supplies biochemists, cell biologists and biophysicists as well as clinicians in immunology, neurology and cardiology with valuable information on Ca2+ signaling mechanisms, functions, dysfunctions and their consequences"--Publisher's description.