Dedication; Preface; Acknowledgements; Contents; Contributors; Chapter 1: Radiographic Imaging in Interstitial Lung Disease and Pulmonary Hypertension; Introduction; Pulmonary Hypertension in Interstitial Lung Disease; Chest X-ray in Interstitial Lung Disease with Pulmonary Hypertension; HRCT in IPF with Pulmonary Hypertension; HRCT in NSIP with Pulmonary Hypertension; HRCT in Respiratory Bronchiolitis and Interstitial Lung Disease (RB-ILD); HRCT in Cryptogenic Organizing Pneumonia (COP) with Pulmonary Hypertension.

Evaluation of Vascular Changes in ILDs IPF; Vascular Remodeling and Angiogenesis in IPF; Angiogenic and Angiostatic Imbalance in IPF; Possible Shared Pathogenic Mechanisms between IPF and PH; Influence of Angiogenesis/Vascular Remodeling on Pulmonary Fibrogenesis and Vice Versa; SSc-Associated ILD; Sarcoidosis; Vascular Changes in Pulmonary Sarcoidosis; Vascular Changes in Sarcoidosis-Associated PH; Pulmonary Langerhans Cell Histiocytosis (PLCH); References; Chapter 4: Treatment of Pulmonary Hypertension in Interstitial Lung Disease; Introduction; Rationale to Treat.

HRCT in Acute Interstitial Pneumonia (AIP) with Pulmonary Hypertension HRCT in Desquamative Interstitial Pneumonia (DIP); HRCT in Lymphocytic Interstitial Pneumonia (LIP); HRCT and PH in the Complications of ILD; IPF and Superimposed Acute Thromboembolic Disease; HRCT in Acute Exacerbation of IPF and Pulmonary Hypertension; HRCT in Combined Pulmonary Fibrosis and Pulmonary Emphysema (CPFE); Cardiogenic Pulmonary Edema; Orphan Lung Diseases and Pulmonary Hypertension; Glossary; References; Chapter 2: Invasive Techniques for Diagnosis of PH; Introduction; Methodological Considerations.

Measurements and Definitions Resting Hemodynamics and Prognosis in PH; PH "Out of Proportion"; Interventions During RHC; Exercise; Fluid Challenge; Vasodilator Challenge; Conclusion; References; Chapter 3: Pathology of Vascular Changes in Interstitial Lung Diseases; Introduction; General Considerations; Normal Microanatomy of the Pulmonary Circulation; Normal Pulmonary Arteries; Normal Pulmonary Veins; Hemodynamic Consequences; Angiogenesis; Vascular Remodeling; Arterial Remodeling; Venous Remodeling; Pathology of Vascular Changes in ILDs.

Results of Prior Studies Selecting the Appropriate Population to Treat; Treatment of Pulmonary Hypertension in Interstitial Lung Disease; Treatment of Pulmonary Hypertension in Sarcoidosis; Future Directions; Conclusion; References; Chapter 5: Lung Transplantation in Interstitial Lung Disease; Overview; Pretransplant Considerations; Timing of Transplant Referral; Comorbidities; Pulmonary Hypertension; Esophageal Dysfunction; Contraindications; Bridge Therapies to Transplant; Operative Considerations; Type of Procedure; Single versus Double Lung Transplant.

The first edition of this book, published in 2009, was the only book of its kind dedicated exclusively to the diagnosis and management of pulmonary arterial hypertension (PAH) in patients with interstitial lung disease (ILD). Over the past few years, new diagnostic tests and treatments of pulmonary arterial hypertension have been developed and tested. Diagnostic testing has led to more frequent and specific diagnosis in PAH patients, leading to the more widespread use of effective treatment and improved quality of life and reduction of mortality for PAH patients. Pulmonary Hypertension and Interstitial Lung Disease: A Clinical Guide, Second Edition provides an updated and expanded state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. The first section of the book discusses general features and includes an overview of clinical features, diagnosis and pathology of ILD. The second part discusses specific disorders such as idiopathic pulmonary fibrosis, sarcoidosis, and hypersensitivity pneumonia. Pulmonary Hypertension and Interstitial Lung Disease, Second Edition is an invaluable resource for all physicians whose practice involves the care and treatment of patients with interstitial lung disease.