SpringerLink Springer Biomedical and Life Sciences eBooks 2017 English+International

Preface; Contents; Part I: Immunology; Chapter 1: Notch Ligands for Lymphocyte Development; 1.1 Introduction; 1.2 General Information of Notch Ligands; 1.2.1 Basic Structure; 1.2.2 Endocytosis of Notch Ligand Is Essential for Signal Induction; 1.2.3 Preferential Interaction with Fringe-Modified Notch; 1.3 Notch Ligand in the Bone Marrow; 1.3.1 Jag1-Mediated Notch Signaling for the Maintenance of Hematopoietic Stem Cells; 1.3.2 Dll4-Induced Weak Notch Signaling Is Present in the BM; 1.4 Notch Ligand in the Thymus; 1.4.1 The Indispensable Role of Dll4 for the Determination of T Cell Fate

1.4.2 Dll4 Is Required for Further Developmental Processes1.5 Notch Ligand in Secondary Lymphoid Organs; 1.5.1 Spleen; 1.5.2 Lymph Node; 1.5.3 Antigen-Presenting Cells; 1.6 Concluding Remarks; References; Chapter 2: Notch Controls the Differentiation and Function of Cytotoxic CD8 T Cells; 2.1 Introduction; 2.2 Notch Signaling in CD4/CD8 Lineage Choice in Developing T Cells; 2.3 Notch Signaling in Controlling T Cell Cytotoxicity; 2.4 Notch Signaling in the Choice of CD8 T Cells to Effector or Memory; 2.5 Notch Signaling as a Therapeutic Target for Clinical Disorders

2.6 Tumor Cells Suppress Notch Signaling in CD8 T Cells to Escape Immunosurveillance2.7 Concluding Remarks; References; Chapter 3: Notch and Myeloid Cells; 3.1 Introduction; 3.2 The Ontology of Dendritic Cells and Their Differentiation Is Regulated by Notch Signaling; 3.3 DC Function; 3.4 Monocyte Development; 3.5 Macrophage Differentiation; 3.6 Macrophage Polarization; 3.7 Cross Talk with TLR Signaling; 3.8 Macrophage Function; 3.9 Conclusions; References; Chapter 4: Taking CD4 T Cells Up a Notch; 4.1 Introduction; 4.2 The Notch Pathway in a Nutshell

4.3 T Helper Cell Activation, Survival, and Memory4.4 T Helper Cell Differentiation and Notch; 4.4.1 Th1 Cell Differentiation; 4.4.2 Th2 and Th9 Cell Differentiation; 4.4.3 Th17 and Th22 Cell Differentiation; 4.4.4 Tfh Cell Differentiation; 4.5 Tolerogenic T Cells; 4.6 Concluding Remarks; References; Part II: Cancer; Chapter 5: NOTCH in Malignant Lymphoma; 5.1 Introduction; 5.2 Genetic Aberrations of NOTCH Genes in Mature B-Cell Neoplasms: Prologue; 5.3 NOTCH1 Mutations in Chronic Lymphocytic Leukemia; 5.4 Mutations of NOTCH2 and Other NOTCH Pathway Genes in Splenic Marginal Zone Lymphoma

5.5 NOTCH1 and NOTCH2 Mutations in Mantle Cell Lymphoma5.6 NOTCH Pathway Gene Mutations in Diffuse Large B-Cell Lymphoma; 5.7 NOTCH Pathway Gene Mutations in Other Mature B-Cell Neoplasms; 5.8 Perspectives and Speculations; 5.8.1 Physiologic NOTCH Signaling in Mature B Cells.; 5.8.2 NOTCH Signaling in B-Cell Activation; 5.8.3 NOTCH Signaling and Epigenetic Regulation; 5.8.4 NOTCH Signaling and Tumor Microenvironment; 5.8.5 Implications in Clinical Settings; References; Chapter 6: The Two Faces of Notch in Solid Cancers; 6.1 Cancers Associated with Active Notch Signalling

This book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch regulates many steps of immune cell differentiation or development as well as tumorigenesis of cells. Although there are still many controversial issues regarding the functions or regulatory mechanism of Notch, it is important to summarize all data together in one volume to help facilitate this research area. Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Therefore, this book covering the broad area of Notch in immunology and tumorigenesis will be attractive to many researchers including faculty members and postdoctoral fellows in academia and researchers in the pharmaceutical industry.