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Preface; Acknowledgments; Contents; Abbreviations; 1: Biological Background of Testicular Autoimmunity; 1.1 Introduction; 1.2 Developmental Phase Differences Between Reproductive and Lymphoid Organs; 1.3 Evolution of the Reproductive and Immune Systems; 1.4 Offensive Attack on Germ Cells by Acquired (Adoptive) Immunity; 1.5 Harsh Immunological Fate of Male Haploid Germ Cells (Spermatids/Spermatozoa); 1.6 Endocrinological Relation Between the Testicular and Immune Functions; References; 2: Microcircumstance for Induction and Prevention of Testicular Autoimmunity; 2.1 Introduction.

2.2 Autoimmunogenicity of Spermatids and Spermatozoa2.3 Protection of Autoimmunogenic Spermatids and Spermatozoa by the Blood-Testis Barrier (BTB); 2.4 Protection of Autoimmunogenic Spermatids and Spermatozoa by Various Local Elements Other Than the BTB; 2.5 Cell Populations Involved in the Testicular Immunoregulation; 2.5.1 Sertoli Cells; 2.5.2 Leydig Cells; 2.5.3 Testicular Leukocytes; 2.5.3.1 Macrophages; 2.5.3.2 Dendritic Cells; 2.5.3.3 Lymphocytes; 2.5.3.4 Other Leukocyte Populations; 2.5.4 Peritubular Myoid Cells and Basal Lamina; 2.5.5 Blood Capillary Endothelium.

2.5.6 Lymphatic Capillary Endothelium2.5.7 Testicular Germ Cells (TGC); 2.5.8 Seminal Plasma; 2.6 Resistance to Inflammatory Cell Responses of Various Types in the Testis; 2.6.1 Resistance to Rejection of Allografts in the Testis; 2.6.2 Spontaneous Occurrence of Vasculitis-Like Lesions in the Male Reproductive System; 2.6.3 Spermatic Granulomata by Local Trauma; 2.6.4 Spermatic Granulomata by Testosterone Treatment; 2.6.5 Reproductive Inflammation by Estrogen Treatment; 2.6.6 Reproductive Inflammation by Intravenous Administration of Bordetella pertussis (BP).

2.6.7 Spontaneous Infiltration of Eosinophils and Macrophages in Reproductive Tissues of Congenitally Lymph Node-ƯLacked Mice2.6.8 Multiple Organ-Localized Autoimmunity; 2.6.9 Resistance to Rejection of Transplanted Allogeneic and Xenogeneic Testis; 2.6.10 Successful Transplantation of Allografts and Xenografts by Co-transplantation with Sertoli Cells; 2.6.11 Successful Transplantation of Xenogeneic Spermatogenesis into the Recipient Testis; 2.6.12 Immune Tolerance Induced by Intratesticular Antigen Priming; 2.7 Five-Phased Immunoregulatory Barriers in the Testis.

2.8 Immunological Fragility of the Testicular Microcircumstance2.8.1 Regional Differences in the Integrity of the Immunological Shield by the BTB; 2.8.2 Pro-inflammatory Cytokines in the Testis Under Normal Condition; 2.8.3 Specific Localization of Immune Cells in the Testis Under Normal Condition; 2.8.4 Infiltration of Macrophages into the Testis in Secondary Biliary Cholestasis; 2.8.5 Mononuclear Cell Responses to Primary Testicular Cancer; 2.8.6 Frequent Involvement of Lymphocytic Leukemia in the Testis; 2.8.7 Natural Autoantibodies to Testicular Antigens.

This book provides useful information to researchers interested in immunologic male infertility as well as clinical professionals. It offers complete coverage of testicular autoimmunity, from biological background to recent research data.

Online resource; title from PDF title page (SpringerLink, viewed August 15, 2017).