SpringerLink Springer Biomedical and Life Sciences eBooks 2017 English+International

Incluye referencias bibliográficas e índice

Small RNA-guided transcriptional gene activation (rnaa) in mammalian cells / Long-Cheng Li / Exogenous RNAa. Enhancing neuronogenesis and counteracting neuropathogenic gene haploinsufficiencies by RNA gene activation / Antonello Mallamaci -- Target-recognition mechanism and specificity of RNA activation / Huiqing Cao, Xing Meng, Xiaoxia Wang, Zicai Liang -- Promoter-targeted small activating rnas alter nucleosome positioning / Bin Wang, Yunzhang Hu -- Endogenous RNAa. Endogenous miRNAa: miRNA-mediated gene upregulation / Vera Huang -- Mirna-mediated RNA activation in mammalian cells / Ramani Ramchandran, Pradeep Chaluvally-Raghavan -- RNAa induced by tata box-targeting micrornas / Yijun Zhang, Hui Zhang -- miRNA-mediated RNAa by targeting enhancers / Qingping Zou, Ying Liang, Huaibing Luo, Wenqiang Yu -- RNA activation guided by other RNA. specific increase of protein levels by enhancing translation using antisense oligonucleotides targeting upstream open frames / Xue-Hai Liang, Wen Shen, Stanley T. Crooke -- Repurposing CRISPR system for transcriptional activation / Meng Chen, Lei Stanley Qi -- Developing RNAa-based therapeutics. RNA-mediated gene activation: identifying a candidate RNA for preclinical development / David R. Corey -- Treatment of pancreatic cancer by aptamer conjugated C/EBP[alpha]-saRNA / Sorah Yoon, John J. Rossi -- Treatment of liver cancer by C/EBPA saRNA / Xiaoyang Zhao, Jon Voutila, Stephanos Ghobrial, Nagy A. Habib, Vikash Reebye -- Enhancing angiogenesis in mice by VEGF-targeting small activating RNAs / Tiia A. Turunen, Seppo Ylä-Herttuala, Mikko P. Turunen -- Suppression of prostate cancer metastasis by DPYSL3-targeted saRNA / Benyi Li, Changlin Li -- Development of therapeutic dsP21 for cancer treatment / Moo Rim Kang, Gongcheng Li, Tiejun Pan, Jin-Chun Xing, Long-Cheng Li.

This book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes' 3' termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs). With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug development.