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Incluye referencias bibliográficas e índice

Meiotic divisions: no place for gender equality / Warif El Yakoubi, Katja Wassmann -- Consequences of centrosome dysfunction during brain development / Maddalena Nano, Renata Basto -- Dividing with extra centrosomes: a double edged sword for cancer cells / Alexander D. Rhys, Susana A. Godinho -- Kinetochore malfunction in human pathologies / Bas de Wolf, Geert J.P.L. Kops -- The elephant in the room: the role of microtubules in cancer / Luca Cirillo, Monica Gotta, Patrick Meraldi -- Clinical development of anti-mitotic drugs in cancer / Anna-Maria Olziersky, S. Intidhar Labidi-Galy -- Mitotic dysfunction associated with aging hallmarks / Joana Catarina Macedo, Sara Vaz, Elsa Logarinho -- Unbalanced growth, senescence and aging / Michael Polymenis, Brian K. Kennedy -- The spindle orientation machinery beyond mitosis: when cell specialization demands polarization / Abigail L.D. Tadenev, Basile Tarc.

"This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases"--Publisher's description.