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Multiparticulate drug delivery : formulation, processing and manufacturing / Ali R. Rajabi-Siahboomi, editor.

Contributor(s): Rajabi-Siahboomi, Ali R.
Material type: materialTypeLabelE-bookSeries: (Advances in Delivery Science and Technology).Publisher: New York, NY : Springer, 2017Description: 1 recurso en línea (402 páginas) : ilustraciones (algunas a color).ISBN: 1493970127; 9781493970124.Subject: Sistemas de liberación de fármacosOnline resources: Acceso a este recurso digital (usuarios Universidad Europea de Madrid)Digital Resources
Contents:
Preface; Contents; Contributors; Chapter 1: Overview of Multiparticulate Systems for Oral Drug Delivery; References; Chapter 2: Characterization of Inert Cores for Multiparticulate Dosage Forms; 2.1 Introduction; 2.2 Inert Cores (Pellets); 2.3 Product Quality for Pellets; 2.4 Materials and Manufacturing of Pellets; 2.5 Surface Area of Pellets; 2.6 Particle Size Diameter of Pellets; 2.6.1 Case Study: Effect of a Small Shift in Median Particle Size of Pellets on Drug Release; 2.7 Particle Size Distribution of Pellets.
2.7.1 Case Study: Effect of Particle Size Distribution of Pellets from Different Suppliers on Drug Release2.8 Volume Versus Number Distribution of Pellets; 2.9 Density of Pellets; 2.9.1 True Density of Pellets; 2.9.2 Envelope Density of Pellets; 2.9.3 Bulk Density of Pellets; 2.10 Shape of Pellets; 2.11 Surface Morphology of Pellets; 2.11.1 Specific Surface Area of Pellets; 2.12 Robustness and Processability of Pellets; 2.12.1 Hardness and Tensile Strength of Pellets; 2.12.2 Friability of Pellets; 2.13 Conclusions; References; Chapter 3: The Science and Practice of Extrusion-Spheronization.
3.1 Introduction3.2 Formulation; 3.2.1 General Requirements; 3.2.2 Alternative Pelletization Aids; 3.3 Extrusion; 3.3.1 Extruder Types; 3.3.2 Small-Scale Extrusion; 3.3.3 Feeding Systems: Powder and Liquid; 3.4 Process Parameters; 3.4.1 Process Control and Process Analytical Technologies (PAT); 3.5 Spheronization; 3.5.1 Equipment; 3.6 Mechanism of Spheronization; 3.7 Process Variables; 3.8 Applications; 3.9 Summary and Conclusions; References; Chapter 4: Fluid Bed Technology, Process Robustness, and Scale-Up; 4.1 Introduction: Fluidized Bed Processing; 4.2 Description of the Top Spray Process.
4.3 Bottom Spray Processing: Wurster4.4 Bottom Spray Processing: Hüttlin Fluid Bed Equipment; 4.5 Rotor or Centrifugal Processing; 4.6 General Processing Considerations for Drug Layering or Film Coating; 4.6.1 Heat and Mass Transfer; 4.6.2 Substrate Flow; 4.6.3 Droplet Size; 4.6.4 Liquid Properties; 4.7 Scale-Up Considerations; 4.8 Summary; References; Chapter 5: Mini-tabs: Versatile Multiparticulate Option for Oral Drug Delivery; 5.1 Introduction; 5.2 Manufacture of Mini-tabs; 5.3 Coating of Mini-tabs; 5.4 Mini-tab Filling into Hard-Shell Capsules.
5.5 Dispensing of Mini-tabs for Better Patient Compliance5.6 Mini-tab Testing; 5.6.1 Disintegration Testing; 5.6.2 Dissolution Testing; 5.6.2.1 Case Study 1: Dissolution Testing of Enteric-Coated Mini-tabs; 5.6.2.2 Case Study 2: Dissolution Testing of Hydrophilic ER Mini-Matrices; 5.7 Mini-tabs in Modified Drug Release Applications; 5.7.1 Delayed Release; 5.7.2 Mini-tabs Coated with Extended Release Coating Systems; 5.7.3 Extended Release Mini-matrices; 5.7.4 Coated Extended Release Mini-matrices; 5.8 Other Applications of Mini-tabs; 5.9 Conclusions; References.
Abstract: Authored by leading experts from academia, users and manufacturers, this book provides an authoritative account of the science and technology involved in multiparticulate drug delivery systems which offer superior clinical and technical advantages over many other specialized approaches in drug delivery. The book will cover market trends, potential benefits and formulation challenges for various types of multiparticulate systems. Drug solubility, dose, chemistry and therapeutic indications as well as excipient suitability coupled with manufacturing methods will be fully covered. Key approaches for taste-masking, delayed release and extended release of multiparticulates systems are of significant interest, especially their in-vivo and in-vitro performance. In addition, the principles of scale-up, QbD, and regulatory aspects of common materials used in this technology will be explained, as well as recent advances in materials and equipment enabling robust, flexible and cost-effective manufacture. Case studies illustrating best practices will also make the book a valuable resource to pharmaceutical scientists in industry and academia.
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Item type Current library Collection Call number Status Date due Barcode Item holds
LIBRO-E NO PRÉSTAMO LIBRO-E NO PRÉSTAMO Madrid Digital Acceso Electrónico (UEM) Ciencias de la Salud RS199.5 M858 2017 EB (Browse shelf(Opens below)) Acceso electrónico eBook.20023727
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Chapter 6: Science and Practice of Microencapsulation Technology.

SpringerLink Springer Biomedical and Life Sciences eBooks 2017 English+International

Incluye referencias bibliográficas e índice

Preface; Contents; Contributors; Chapter 1: Overview of Multiparticulate Systems for Oral Drug Delivery; References; Chapter 2: Characterization of Inert Cores for Multiparticulate Dosage Forms; 2.1 Introduction; 2.2 Inert Cores (Pellets); 2.3 Product Quality for Pellets; 2.4 Materials and Manufacturing of Pellets; 2.5 Surface Area of Pellets; 2.6 Particle Size Diameter of Pellets; 2.6.1 Case Study: Effect of a Small Shift in Median Particle Size of Pellets on Drug Release; 2.7 Particle Size Distribution of Pellets.

2.7.1 Case Study: Effect of Particle Size Distribution of Pellets from Different Suppliers on Drug Release2.8 Volume Versus Number Distribution of Pellets; 2.9 Density of Pellets; 2.9.1 True Density of Pellets; 2.9.2 Envelope Density of Pellets; 2.9.3 Bulk Density of Pellets; 2.10 Shape of Pellets; 2.11 Surface Morphology of Pellets; 2.11.1 Specific Surface Area of Pellets; 2.12 Robustness and Processability of Pellets; 2.12.1 Hardness and Tensile Strength of Pellets; 2.12.2 Friability of Pellets; 2.13 Conclusions; References; Chapter 3: The Science and Practice of Extrusion-Spheronization.

3.1 Introduction3.2 Formulation; 3.2.1 General Requirements; 3.2.2 Alternative Pelletization Aids; 3.3 Extrusion; 3.3.1 Extruder Types; 3.3.2 Small-Scale Extrusion; 3.3.3 Feeding Systems: Powder and Liquid; 3.4 Process Parameters; 3.4.1 Process Control and Process Analytical Technologies (PAT); 3.5 Spheronization; 3.5.1 Equipment; 3.6 Mechanism of Spheronization; 3.7 Process Variables; 3.8 Applications; 3.9 Summary and Conclusions; References; Chapter 4: Fluid Bed Technology, Process Robustness, and Scale-Up; 4.1 Introduction: Fluidized Bed Processing; 4.2 Description of the Top Spray Process.

4.3 Bottom Spray Processing: Wurster4.4 Bottom Spray Processing: Hüttlin Fluid Bed Equipment; 4.5 Rotor or Centrifugal Processing; 4.6 General Processing Considerations for Drug Layering or Film Coating; 4.6.1 Heat and Mass Transfer; 4.6.2 Substrate Flow; 4.6.3 Droplet Size; 4.6.4 Liquid Properties; 4.7 Scale-Up Considerations; 4.8 Summary; References; Chapter 5: Mini-tabs: Versatile Multiparticulate Option for Oral Drug Delivery; 5.1 Introduction; 5.2 Manufacture of Mini-tabs; 5.3 Coating of Mini-tabs; 5.4 Mini-tab Filling into Hard-Shell Capsules.

5.5 Dispensing of Mini-tabs for Better Patient Compliance5.6 Mini-tab Testing; 5.6.1 Disintegration Testing; 5.6.2 Dissolution Testing; 5.6.2.1 Case Study 1: Dissolution Testing of Enteric-Coated Mini-tabs; 5.6.2.2 Case Study 2: Dissolution Testing of Hydrophilic ER Mini-Matrices; 5.7 Mini-tabs in Modified Drug Release Applications; 5.7.1 Delayed Release; 5.7.2 Mini-tabs Coated with Extended Release Coating Systems; 5.7.3 Extended Release Mini-matrices; 5.7.4 Coated Extended Release Mini-matrices; 5.8 Other Applications of Mini-tabs; 5.9 Conclusions; References.

Authored by leading experts from academia, users and manufacturers, this book provides an authoritative account of the science and technology involved in multiparticulate drug delivery systems which offer superior clinical and technical advantages over many other specialized approaches in drug delivery. The book will cover market trends, potential benefits and formulation challenges for various types of multiparticulate systems. Drug solubility, dose, chemistry and therapeutic indications as well as excipient suitability coupled with manufacturing methods will be fully covered. Key approaches for taste-masking, delayed release and extended release of multiparticulates systems are of significant interest, especially their in-vivo and in-vitro performance. In addition, the principles of scale-up, QbD, and regulatory aspects of common materials used in this technology will be explained, as well as recent advances in materials and equipment enabling robust, flexible and cost-effective manufacture. Case studies illustrating best practices will also make the book a valuable resource to pharmaceutical scientists in industry and academia.

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